MPXV M2 impairs T cell activation mediated by B7 costimulation B7-mediated signaling is required for T cell immunity, we then investigated the biological effects of M2 on hB7.1/2 costimulatory functions via an ex vivo T cell activation assay. Purified T cells from peripheral blood mononuclear cel...
OBJECTIVE: The immunogenicity of abatacept, a selective costimulation modulator, administered intravenously, was assessed across Phase II and III trials in patients with rheumatoid arthritis (RA). METHODS: Two direct-format enzyme-linked immunosorbent assays evaluated antibody responses [whole abatacept molec...
Oncology Modulating Costimulation to Break T Cell Tolerance| Potential Therapeutic Insight into Breaking Tolerance to Tumor Antigens UNIVERSITY OF CONNECTICUT Adam Adler St. RoseMarie-ClareTumor-associated antigens (TAAs) are a form of self-antigens, and thus tumor immunity can be dampened by the ...
摘要: The CD40L molecule expressed by CD4+ regulatory T lymphocytes is known to deliver signals that activate B cells and macrophages. It now appears that CD40L regulates T cells themselves, during both their development and their participation in adaptive immune responses.关键词:...
Regulation of T cell activation in experimental autoimmune encephalomyelitis: Significance of CD28-mediated costimulation and immune function of CNS-resident cells. 热度: A quantitative analysis of antigen-presenting cell function activated B cells stimulate naive CD4 T cells but are inferior to ...
Kremer JMet al. (2003) Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig.N Engl J Med349: 1907–1915 ArticleCASGoogle Scholar Kremer JMet al. (2005) Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept: twelve...
A growing body of evidence suggests that T-cell costimulation signals might be implicated in the pathogenesis of SSc. CD28, CTLA-4, ICOS, and OX40L ... G Boleto,Y Allanore,J Avouac - 《Frontiers in Immunology》 被引量: 0发表: 2018年 Abstract 1265: Sustained PI3-kinase signaling is medi...
Fas costimulation of naive CD4T cells is controlled by NF-kappaB signaling and caspase activity. J Leukoc Biol 2006; 79: 369–377. 7. Kataoka T, Tschopp J. N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB ...
T cell activationcostimulationimmunotherapyToll-like receptors (TLRs) are among the fundamental molecules that alert the immune system to the presence of an ... N Asprodites,L Zheng,D Geng,... - 《Faseb Journal Official Publication of the Federation of American Societies for Experimental Biology》...
T-Cell Costimulation and Coinhibition in Graft-Versus-Host Disease and Graft-Versus-Leukemia Effectdoi:10.1016/B978-0-12-812630-1.00011-6Yongxia WuClaudio AnasettiXue-Zhong YuImmune Biology of Allogeneic Hematopoietic Stem Cell Transplantation (Second Edition)...