During activation, T cells undergo extensive gene expression changes that shape the properties of cells to exert their effector function. Understanding the regulation of this process could help explain how genetic variants predispose to immune diseases. Here, we mapped genetic effects on gene expression...
T-cell activation T-cell function is intimately tied to the activation process. Activation is required for the naïve T cell to acquire an effector or memory phenotype. A second round of activation is required to elicit effector cytokine production from the effector or memory T cell. Full acti...
Clonal T cell expansion is the process of T cell activation and proliferation which occurs naturallyin vivowhen the human body is actively fighting an infection or an immune system attack.In vitro, clonal T cell expansion happens when a naïve T cell recognizes and binds to a spe...
All proteins are directly measured on protein level and thus represent an experimentally validated set of cell surface proteins involved in the T-cell activation process. Next, a cell surface expression atlas based on transcriptomic data, annotations based on experimental evidence as well as predicted...
T cell activation initiates the process whereby quiescent, naive T cells differentiate into rapidly proliferating effector cells. This transition involves a profound and dynamic metabolic reprograming. After the resolution of an immune response, some T cells transition to memory cells: these cells are ...
Upon recognition, their purpose becomes the removal of virally infected cells, bacteria, and tumor fragments (such as cancer cells) through a process called apoptosis. Apoptosis occurs when a cell’s internal organelles are destroyed causing it to die from the inside out. Helper T Cells T ...
Intravital real-time analysis of T-cell activation in health and disease Antigenic activation is a central process in T-cell biology essential for efficient protection of the host from infections and tumors by the adaptive immun... Dmitri,Lodygin,Alexander,... - 《Cell Calcium》 被引量: 4发表...
nuclear factor of activated T cells (NFAT), IL-2 or other kinds of factors will be detected by bioluminescent methods or ELISA kits. Meanwhile, the T cell activation and proliferation process can also be evaluatedviacell counting kit-8 (CCK-8), MTT, CFSE as well as flow cytometric ...
and these engineered T cells were well tolerated and preserved the original therapeutic effects, but accompanied by reduced chromosomal loss. By adjusting the CAR-T cells preparation process and altering the sequence of T cell activation and Cas9 gene editing, researchers can effectively reduce the fr...
Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells. Nat. Immunol. 12, 478–484 (2011). Article CAS PubMed PubMed Central Google Scholar Smith-Garvin, J. E., Koretzky, G. A. & Jordan, M. S. T cell activation. Annu. Rev. Immunol. 27, 591–619 ...