Resources for T cell activation What is clonal T cell expansion? Clonal T cell expansion is the process of T cell activation and proliferation which occurs naturally in vivo when the human body is actively fighting an infection or an immune system attack. In vitro, clonal T cell ...
During activation, T cells undergo extensive gene expression changes that shape the properties of cells to exert their effector function. Understanding the regulation of this process could help explain how genetic variants predispose to immune diseases. Here, we mapped genetic effects on gene expression...
T-cell function is intimately tied to the activation process. Activation is required for the naïveT cellto acquire an effector or memory phenotype. A second round of activation is required to elicit effectorcytokine productionfrom the effector or memory T cell. Full activation of a T cell req...
T-cell activation refers to a process in which mature T cells, which express antigen-specific T-cell receptors on their surfaces, recognize their cognate antigens and respond by entering the cell cycle, secreting cytokines or lytic enzymes, and initiating the cell-based functions of the immune ...
nuclear factor of activated T cells (NFAT), IL-2 or other kinds of factors will be detected by bioluminescent methods or ELISA kits. Meanwhile, the T cell activation and proliferation process can also be evaluatedviacell counting kit-8 (CCK-8), MTT, CFSE as well as flow cytometric ...
The recognition of foreign antigen by T cells is the foundation of the adaptive immune response, and this has been demonstrated experimentally to be an extremely sensitive, specific and reliable process. In this thesis, models for T cell signalling based on recent experimental data are constructed ...
Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells. Nat. Immunol. 12, 478–484 (2011). Article CAS PubMed PubMed Central Google Scholar Smith-Garvin, J. E., Koretzky, G. A. & Jordan, M. S. T cell activation. Annu. Rev. Immunol. 27, 591–619 ...
【4】Driving T cells into the TME is a gradual process (Figure 2): tumor cell death and antigen release, antigen-presenting cell (APC) processing and presentation of tumor antigens, and APC and T-cell interactions lead to T-cell priming...
Upon recognition, their purpose becomes the removal of virally infected cells, bacteria, and tumor fragments (such as cancer cells) through a process called apoptosis. Apoptosis occurs when a cell’s internal organelles are destroyed causing it to die from the inside out. 3. Helper T Cells ...
2d–g). These data collectively show that Arih1-WT-OE in tumor cells can induce CD8+ T cell activation and improve the efficacy of PD-L1 blockade. Fig. 2: ARIH1 enhances anti-PD-L1 antibody-induced anti-tumor immunity in 4T1 tumor models. a Tumor growth curves in female BALB/c mice...