During activation, T cells undergo extensive gene expression changes that shape the properties of cells to exert their effector function. Understanding the regulation of this process could help explain how genetic variants predispose to immune diseases. Here, we mapped genetic effects on gene expression...
Detection of antigen-specific CD4+ T cells by HLA-DR1 oligomers in dependent on an active cellular process J. Immunol., 166 (2001), pp. 741-745 CrossrefView in ScopusGoogle Scholar Cantrell, 1996 D. Cantrell T cell antigen receptor signal transduction pathways Annu. Rev. Immunol., 14 (19...
T-cell activation T-cell function is intimately tied to the activation process. Activation is required for the naïve T cell to acquire an effector or memory phenotype. A second round of activation is required to elicit effector cytokine production from the effector or memory T cell. Full acti...
Clonal T cell expansion is the process of T cell activation and proliferation which occurs naturallyin vivowhen the human body is actively fighting an infection or an immune system attack.In vitro, clonal T cell expansion happens when a naïve T cell recognizes and binds to a sp...
T cell activation initiates the process whereby quiescent, naive T cells differentiate into rapidly proliferating effector cells. This transition involves a profound and dynamic metabolic reprograming. After the resolution of an immune response, some T cells transition to memory cells: these cells are ...
Intravital real-time analysis of T-cell activation in health and disease Antigenic activation is a central process in T-cell biology essential for efficient protection of the host from infections and tumors by the adaptive immun... Dmitri,Lodygin,Alexander,... - 《Cell Calcium》 被引量: 4发表...
Upon recognition, their purpose becomes the removal of virally infected cells, bacteria, and tumor fragments (such as cancer cells) through a process called apoptosis. Apoptosis occurs when a cell’s internal organelles are destroyed causing it to die from the inside out. Helper T Cells T ...
We propose a model that describes the initial process of T-cell receptor (TCR) activa- tion. An e cient T cell can recognize agonist pMHC with high speci city, sensitivity, and speed. The assistance of CD45 is also required for TCR activation. We consider the simulation for single TCR ...
nuclear factor of activated T cells (NFAT), IL-2 or other kinds of factors will be detected by bioluminescent methods or ELISA kits. Meanwhile, the T cell activation and proliferation process can also be evaluatedviacell counting kit-8 (CCK-8), MTT, CFSE as well as flow cytometric ...
Activation ofB cells A B cell becomes activated when its receptor recognizes an antigen and binds to it. In most cases, however, B-cell activation is dependent on a second factor mentioned above—stimulation by an activated helper T cell. Once a helper T cell has been activated by an antige...