Mechanism of the inhibition of T cell activation by immunosuppressant FK506The present study investigates the role of thymic stroma-derived T cell growth factor (TSTGF) in promoting the growth of L3T4- Lyt2- (double-negative) thymocytes. Partially purified TSTGF samples were prepared from the ...
T cells are activated by interaction of cell-surface antigen receptors with major histocompatibility complex (MHC) proteins on the surface of other cells. Studies using soluble oligomers of MHC–peptide complexes and other types of receptor cross-linking agents have supported an activation mechanism ...
There is considerable controversy about the mechanism of T cell receptor (TCR) triggering, the process by which the TCR tranduces signals across the plasma membrane after binding to its ligand (an agonist peptide complexed with an MHC molecule). Three main types of mechanism have been proposed,...
James J R, Vale R D. Biophysical mechanism of T-cell receptortriggering in a reconstituted system[J]. Nature, 2012, 487(7405): 64-69. Tischer D K, Weiner O D. Light-based tuning of ligand half-life supports kinetic proofreading model of ...
T cell-mediated responses have been implicated in the development of fibrosis, impaired lymphangiogenesis, and lymphatic dysfunction in secondary lymphedema. Here we show that CD4+ T cells are necessary for lymphedema pathogenesis by utilizing adopt
[1] Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various ...
Activation-induced cell death (AICD) is a mechanism of peripheral T cell tolerance that depends upon an interaction between Fas and Fas ligand (FasL). Alth... J Zhang,JX Gao,K Salojin,... - 《Journal of Experimental Medicine》 被引量: 177发表: 2000年 Mechanism of activation-induced cell...
the body mounts a second immune response that is led by these long-lasting memory cells, which then give rise to another population of identical effector and memory cells. This secondary mechanism is known asimmunological memory, and it is responsible for the lifetime immunities to diseases such...
我們將單一個T細胞受體活化反應過程簡化為一個對於自由的T細胞受體( free TCR) 和TCR-pMHC複合體而言皆為具有可逆修飾作用的反應模型,並且研究kinetic proofreading mechanism及CD45在T細胞受體活化反應中的效用.研究結果顯示,(1)在缺乏CD45時,kinetic proofreading在合理範圍的pMHC濃度下無法幫助T細胞降低出錯率,其主要...
适用于(应用)Activation and Expansion of T-cells 材质磁性聚苯乙烯 产品类型抗体包被微球 最终产品类型细胞 适用于(设备)DynaMag™ Magnet 宿主种属小鼠 分离技术Magnetic Beads 产品线DYNAL™、Dynabeads™ 反应性人 样品类型细胞培养,PBMC 有效期24个月 ...