Mechanism of the inhibition of T cell activation by immunosuppressant FK506The present study investigates the role of thymic stroma-derived T cell growth factor (TSTGF) in promoting the growth of L3T4- Lyt2- (double-negative) thymocytes. Partially purified TSTGF samples were prepared from the ...
Biophysical cues play a crucial role in T cell biology, yet their implications in adoptive T cell therapy remain elusive. Here the authors use a charged substrate to enhance T cell proliferation and anti-tumor function for adoptive transfer therapy, with the mechanism of amplifying TCR signaling,...
are now implicated as markers or associated with T cell exhaustion. The downstream pathways and regulatory mechanisms of most inhibitory receptors are still unknown, and even those that do have a proposed mechanism would likely benefit from an unbiased global profiling of the dynamics of phosphorylatio...
A T cell-independent mechanism of macrophage activation by interferon-gamma. A T cell-independent mechanism of macrophage activation by interferon ␥. J. Immunol. 139: 1104 -1107.Bancroft, G. J., R. D. Schreiber, G. C... GJ Bancroft,RD Schreiber,GC Bosma,... - 《Journal of Immunolog...
T-cell activation is a critical driver of immune responses. The CD28 costimulation is an essential regulator of CD4 T-cell responses, however, its relative importance in naive and memory T cells is not fully understood. Using different model systems, we
[1] Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various ...
lymphocytes. Induction of nonlymphoid FasL in this manner may serve as a sensing mechanism for immune cell infiltration, which contributes to peripheral deletion. 展开全部 机器翻译 AI理解论文&经典十问 挑战十问 Request failed with status code 503...
These results reveal a target cell-dependent mechanism of T-cell activation by blinatumomab and suggest that TNFSF4 may be responsible for the resistant mechanism and a potential target for combination therapy with blinatumomab, to treat B-ALL or other B-cell malignancies. ...
Studies using soluble oligomers of MHC–peptide complexes and other types of receptor cross-linking agents have supported an activation mechanism that involves T cell receptor clustering. Receptor clustering induced by incubation of T cells with MHC–peptide oligomers leads to the induction of T-cell ...
Consistent with the known mechanism of FTY720, we found that FTY720-treated PLND-operated mice had significantly more CD4+ T cells in the ipsilateral inguinal lymph nodes compared to those treated with control (Fig. 8b, d). More importantly, FTY720 treatment resulted in significantly fewer CD4+ ...