Antibody and chimeric antigen receptor (CAR) T cell-mediated targeted therapies have improved survival in patients with solid and haematologic malignancies1–9. Adults with T cell leukaemias and lymphomas, collectively called T cell cancers, have short s
The source of the T cell is indicated in the bottom row. f, Venn diagram showing the lack of overlap between T cell clones from separate mice, for the four mice for which the TCR repertoire was analysed by single-cell RNA-seq via TraCeR. TCR-β sequences were used, and all unique ...
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The experimental evidence for their localization on the cell surface is brought by the PAL-qLC-MS/MS approach. In addition, proteins already nomenclatured as CD molecules were also included in further analysis supplemental Fig. S3 displays a Venn diagram and gives an overview of the number of ...
a Scatter diagram of Th1 cells. b Statistical analysis of the percentage of Th1 cells in each group. c Scatter diagram of Th2 cells. d Statistical analysis of the proportion of Th2 cells in each group (*P < 0.05; **P < 0.01; ***P < 0.001) that the degree of ...
Figure 6. Outside Signaling: HMBPP Increases the Binding Force between a Vγ9Vδ2 T Cell and a Target Cell (A) A schematic diagram for the atomic-force-microscopy-based single-cell force spectroscopy (AFM-SCFS) experiment. (B) Adhesion forces between individual Vγ9Vδ2 T cells and indiv...
(B) Diagram of CAR protein in the cell membrane showing the extracellular single-chain Fv (scFv) domain and the transmembrane (TM) and signaling domains that combine CD28 and CD3z C termini. (C) Steps involved in the isolation, activation, and transduction of CD8+ splenocytes with virus ...
from its bulk stiffness by varying the degree of covalent crosslinking via a bioorthogonal click reaction with tetrazine moieties, we show that ECM viscoelasticity regulates T-cell phenotype and function via the activator-protein-1 signalling pathway, a critical regulator of T-cell activation and ...
CD4+ T cell activation is required for lymphedema. a Schematic diagram of adoptive transfer of CD45.1+ DCs following PLND or sham surgery. Mice killed 2 weeks after surgery. b, c FACS quantification of CD45.1+CD11c+MHCII+CD86+ cells in ipsilateral inguinal lymph nodes (b) and hindlimb sk...
CAR-BCMA contained the 11D5-3 anti-BCMA single chain variable fragment (scFv), CD8α hinge and transmembrane regions, the cytoplasmic portion of the CD28 costimulatory moiety, and the CD3ζ T-cell activation domain. (B) CAR-BCMA expression on the surface of the infusion T cells of ...