The present invention provides, among other things, methods of increasing T-cell activation in a subject, comprising administering to the subject a composition that inhibits hematopoietic progenitor kinase 1 (HPKl). The composition may comprise, for example, a small molecule HPKl inhibitor. The ...
54 Clearly, T cell responses to antigen and their environment are complex and dynamic, and hence the use of unbiased, global, systems-level proteomic and phosphoproteomic profiling methods, as outlined in depth below, offer an excellent basis for exploring these important but under-appreciated ...
2021 年 3 月 23 日,来自加拿大蒙特利尔大学的 Etienne Gagnon 教授带领团队,在Science子刊Science Signaling发表题为 TMEM16F mediates bystander TCR-CD3 membrane dissociation at the immunological synapse and potentiates T cell activation 的研究 [1],研究揭示了 TMEM16F 在旁观者 TCR 诱导信号放大中关键作用,并...
在Science子刊Science Signaling发表题为TMEM16F mediates bystander TCR-CD3 membrane dissociation at the immunological synapseand potentiates T cell activation的研究 [1],研究揭示了 TMEM16F 在旁观者 TCR 诱导信号放大中关键作用,并确定了 TMEM16F 功能的增强作为促进 T 细胞活化的潜在治疗策略。
Each type of T cell can help us to learn about diseases and our bodies’ responses to them. Naïve T cells teach us about adaptability; effector cells give us ideas for methods of treatment such as TCR therapy; memory T cells assist us in creating vaccines and medicine. T cells are an...
T-cell activation is essential for initiation and control of immune system function. T cells are activated by interaction of cell-surface antigen receptors with major histocompatibility complex (MHC) proteins on the surface of other cells. Studies using soluble oligomers of MHC–peptide complexes and...
Over decades, numerous methods to stimulate T cells in vitro have been established. Most of them take advantage of T cell biology, primarily targeting the engagement of the T cell receptor (TCR) that initiates sufficient intracellular signal transduction and drives productive activation, proliferation,...
This process resulted in high-quality data for 655,349 cells (Methods and Supplementary Fig. 1c–g). Fig. 1: A single-cell transcriptional map of CD4+ T cell activation. a, Schematic of the study design. b, UMAP embedding of scRNA-seq data for unstimulated CD4+ T cells and at three...
Isolating pure cell populations from peripheral blood using standard venipuncture methods is often not a scalable source for the demands of cellular research. Leukopaks, an apheresis product, is a human peripheral blood mononuclear cells (PBMC) rich material that can be preserved and shipped as a ...
Fluorescent dyes that stain cell membranes or cytoplasm and then partition between daughter cells at division have been used in conjunction with flow cytom... AL Givan,JL Fisher,M Waugh,... - 《Journal of Immunological Methods》 被引量: 287发表: 1999年 CD4+ T-cell clones obtained from catt...