Target cell-bound CC-3 was capable of inducing TCR/CD3 engagement in a concentration-dependent manner, as shown by a T cell activation bioassay (Fig. 3A). Next, we used the Jurkat reporter cell line J76TPR [35] to determine CC-3 mediated induction of the transcription factors NFAT (GFP...
cell receptors causing T-cell activation in the absence of target cells. We, therefore, subtracted the background signal generated by the PTEs that carried only T-cell antibodies (Supplementary Fig.6). Here aCD19 × aCD3 constructs lead to the strongest T-cell activation, whereas aCD22 × ...
Development of a bioassay to detect T-cell-activating impurities for T-cell-dependent bispecific antibodies 来自 Springer 喜欢 0 阅读量: 52 作者:HY Lee,E Contreras,AC Register,Q Wu,K Abadie,K Garcia,PY Wong,G Jiang 摘要: T-cell-dependent bispecific antibodies (TDBs) are promising cancer ...
The cytochrome c-sensitive TCR-expressing hybridoma (2B4) was stimulated with pigeon cytochrome c antigen, anti-CD3 crosslinking, or PMA and ionomycin, in the presence or absence of CP, and the resulting IL-2 produced was measured in a bioassay using an IL-2-dependent cell line (CTLL-2)....
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The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration range of 1.0-10ng/ml.Physical Appearance Sterile Filtered White lyophilized (freeze-dried) powder.Formulation Lyophilized from a 0.2μm filtered concentrated solution in 20mM PB, pH7.4, 150mM ...
We have investigated the inhibitory effects of CsA and FK506 on the direct response of human CD4+ T cells to HUVEC and PAEC and the effect of adding B7-1 transfectants.T cell proliferation, interleukin-2 release bioassays and a multiple cytokine bioassay employing the TF-1 cell line were ...
中文名称:重组人活化调控正常T细胞表达序列/CCL5英文名称:Recombinant Human Regulation upon Activation Normal T cell Express Sequence/CCL5 产品类别:重组蛋白 趋化因子 Biological Activity Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human ...
Immunotherapy elicits a systemic antitumour immune response in peripheral circulating T cells. However, the T cell trafficking circuit between organs and their contributions to antitumour immunity remain largely unknown. Here we show in multiple mouse le
Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration range of 1.0-10ng/ml. Physical Appearance Sterile Filtered White lyophilized (freeze-dried) powder. ...