T Cell Activation Is Associated with Lower CD4[sup+] T Cell Gains in Human Immunodeficiency Virus--Infected Patients with Sustained Viral Suppression during Antiretroviral Therapy.T Cell Activation Is Associated with Lower CD4[sup+] T Cell Gains in Human Immunodeficiency Virus--Infected Patients with...
Heather L. ParrishCaleb R. GlassmanMadeline M. KeenenNeha R. DeshpandeMatthew P. BronnimannMichael S. KuhnsHuet S, Groux H, Caillou B, Valentin H, Prieur AM, Bernard A (1989) CD44 contributes to T cell activation. J Immunol 143:798- 801...
Variants associated with immune-mediated diseases are enriched in enhancers and promoters whose activity is upregulated upon CD4+ T cell activation11,12. However, CD4+ T cells comprise naive cells, which have not yet encountered an antigen, and memory cells, which have previously undergone activatio...
Appropriate activation of CD4+ T cells is fundamental for efficient initiation and progression of acquired immune responses. Here, we showed that CD4+ T-cell activation is dependent on changes in membrane n-3 polyunsaturated fatty acids (PUFAs) and is dynamically regulated by the type of signals...
Resveratrol, a natural polyphenol compound, has broad effects on critical events, including inflammation, oxidation, cancer and aging. However, the function and molecular mechanisms of resveratrol on T cell activation are controversial. In the present study, we found that resveratrol significantly inhibit...
ADAP plays a pivotal role in CD4(+) T cell activation but is only marginally involved in CD8(+) T cell activation ADAP plays a pivotal role in CD4(+) T cell activation but is only marginally involved in CD8(+) T cell activationintegrinadhesion... Podlasly,Lisa,Parzmair,... - 《...
T helper cells, or CD4+ cells, are similar to cytotoxic cells but have a wider range of functions. These cells are extremely important to cell immunity because they are required for most adaptive immune responses. T helper cells become activated when presented with antigens and have the ability...
Interaction of immature CD4+CD8+ thymocytes with thymic epithelial cells, mediated by MHC-restricted TCRs, allows the cells to receive a protective signal that prevents them from undergoing cell death; cells whose receptors are not MHC restricted,...
When cocultured with CD4+CD25- cells, the CD4+CD25+ cells markedly suppressed proliferation by specifically inhibiting the production of IL-2. The inhibition was not cytokine mediated, was dependent on cell contact between the regulatory cells and the responders, and required activation of the ...
Immune activation markers and CD4+ T-cell counts in HIV-infected intravenous drug users. J Acquir Immune Defic Syndr (1992) 5:1273-4. doi:10.1097/... R Zangerle,H Wachter,D Fuchs - 《Journal of Acquired Immune Deficiency Syndromes》 ...