2024年10月26日，上海交通大学医学院附属瑞金医院陆洁莉团队、英国布里斯托大学等合作在期刊《Nature Communications》上发表了题为“Transcriptome-wide Mendelian randomization during CD4 T cell activation reveals immune-related drug targets for cardiometabolic diseases”的研究论文。在这项研究中，团队观察到162个改变T...
[6]Hong J J, Amancha P K, Rogers K, et al. Spatial alterations between CD4(+) T follicular helper, B, and CD8(+) T cells during simian immunodeficiency virus infection: T/B cell homeostasis, activation, and potential mechanism for viral escape. J Immunol, 2012, 188(7): 3247-3256 [...
近日,来自比利时鲁汶大学的Diether Lambrechts团队在Immunity上发表题为CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy in head and neck squamous carcinoma的文章。通过对...
近日,南方科技大学靳文菲课题组在iScience上发表了题为“Exploring the dynamics and influencing factors of CD4 T cell activation using single-cell RNA-seq”的研究。该研究利用抗CD3/CD28磁珠刺激人静息态T细胞,并对刺激前后的样本进行单细胞转录组测序(scRNA-seq),整合公共数据从细胞亚群、基因表达、细胞-细胞通讯...
[6]Hong J J, Amancha PK, Rogers K,et al.Spatial alterations between CD4(+) T follicular helper, B, and CD8(+) T cells during simian immunodeficiency virus infection: T/B cell homeostasis, activation, and potential mechanism for viral esca...
3、第7天,用PBS洗涤两次细胞后,用1 ml完全培养基 重悬细胞,并且加入2 μl /ml Cell Activation Cocktail without Brefeldin A, 3 μM Monensin,在37°C含有5% CO2条件下孵育6 h。 4、结束刺激后,收集细胞,进行染色实验。 试剂列表 o Sterile PBS ...
2024年12月,四川大学罗有福、杨涛团队在Cell Report Medicine(IF=11.7)上发表了题为“Chemical activation of mitochondrial ClpP to modulate energy metabolism of CD4+ T cell for inflammatory bowel diseases treatment”的研究性论文。论文研究了ATP依赖性线粒体酪蛋白溶解蛋白酶P(ClpP)在IBD中的作用,发现ClpP...
[4] Maes, Michael. T cell activation via the CD40 ligand and transferrin receptor and deficits in T regulatory cells are associated with major depressive disorder and severity of depression. T cell activation via the CD40 ligand and transferrin receptor and deficits in T regulatory cells are ...
目前，LMU Max Avon Pettifogger研究所的Oliver T. Kepler教授首次发现了一种快速又高效的基因编辑方法。这项技术可以改进HIV的生物学功能特征以及提高CD4+T细胞的免疫功能。近日，这项研究的研究结果发表在《Nature Methods》上，题为“Rapid, efficient and activation-neutral gene editing of polyclonal primary human...
Osum KC, Jenkins MK. Toward a general model of CD4+ T cell subset specification and memory cell formation. Immunity. 2023;56(3):475-484. doi:10.1016/j.immuni.2023.02.010 Oh DY, Fong L. Cytotoxic CD4+ T cells in cancer: Expanding the immune effector toolbox. Immunity. 2021;54(12):27...