AlekseyV. Belikov. The role of reactive oxygen species and mitochondria in T-cellactivation. (图1) YoshihiroOhue,Hiroyoshi Nishikawa. Regulatory T (Treg) cells in cancer: Can Treg cellsbe a new therapeutic target? Cancer Sci. 2019 Jul;110(7):2080-2089.(图2) 作者:奇 诺 本文首发于“ 解...
2024年10月26日，上海交通大学医学院附属瑞金医院陆洁莉团队、英国布里斯托大学等合作在期刊《Nature Communications》上发表了题为“Transcriptome-wide Mendelian randomization during CD4 T cell activation reveals immune-related drug targets for cardiometabolic diseases”的研究论文。在这项研究中，团队观察到162个改变T...
近日,来自比利时鲁汶大学的Diether Lambrechts 团队在Immunity上发表题为CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy的文章。通过对患者样本进行单细胞转录组分析,揭示了抗 PD-L1 加抗 CTLA4联合疗法增强了CD4+和CD8+ T细胞的扩张,特别是CD4+ T细胞...
This suggests that PGK1 inhibition prevents the maturation and development of CD4+T cells, Th17 cells, and myeloid cells in the periphery, while promoting the formation of Treg cells. 5. PGK1 regulates CD4+ T cell activation and Th17 cell differentiation in vitro 为了探究PGK1对pathogenic CD4+T...
近日,来自比利时鲁汶大学的Diether Lambrechts团队在Immunity上发表题为CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy in head and neck squamous carcinoma的文章。通过对...
2021年3月4日,中国科学院上海营养与健康研究所肖意传课题组与中国科学院上海药物研究所郑明月课题组合作,在Immunity杂志发表了题为:Cytoplasmic DNA sensing by KU complex in aged CD4+ T cell potentiates T cell activation and aging-related autoimmune inflammation的研究论文。
近期,中国科学院上海营养与健康研究所研究员肖意传课题组与中科院上海药物研究所研究员郑明月合作,在Immunity上,在线发表题为Cytoplasmic DNA sensing by KU complex in aged CD4+ T cell potentiates T cell activation and aging-related a...
近日,明尼苏达大学David Masopust在Nature Immunology上发表了题为CD4+ T cell memory的综述论文,对记忆CD4+ T细胞进行了系统性综述。 图片 记忆CD4+ T细胞的寿命和检测手段 有研究显示,在接种天花疫苗后75年,记忆CD4+ T细胞在体外经抗原特异性肽段的再刺激后仍能产生IFN-γ。麻疹疫苗接种后至少34年、麻腮风疫苗接种...
Osum KC, Jenkins MK. Toward a general model of CD4+ T cell subset specification and memory cell formation. Immunity. 2023;56(3):475-484. doi:10.1016/j.immuni.2023.02.010 Oh DY, Fong L. Cytotoxic CD4+ T cells in cancer: Expanding the immune effector toolbox. Immunity. 2021;54(12):27...
CD4+ T cell activation is required for lymphedema. a Schematic diagram of adoptive transfer of CD45.1+ DCs following PLND or sham surgery. Mice killed 2 weeks after surgery. b, c FACS quantification of CD45.1+CD11c+MHCII+CD86+ cells in ipsilateral inguinal lymph nodes (b) and hindlimb sk...