未来,结合抗原特异性激活与免疫治疗手段,可能会为HIV治愈带来新的曙光。 标题:New breakthrough in HIV cure research, antigen-specific CD4 T cell activation associated with HIV transcription. 作者:PaperplaneTH
2024年10月26日，上海交通大学医学院附属瑞金医院陆洁莉团队、英国布里斯托大学等合作在期刊《Nature Communications》上发表了题为“Transcriptome-wide Mendelian randomization during CD4 T cell activation reveals immune-related drug targets for cardiometabolic diseases”的研究论文。在这项研究中，团队观察到162个改变T...
近日,南方科技大学靳文菲课题组在iScience上发表了题为“Exploring the dynamics and influencing factors of CD4 T cell activation using single-cell RNA-seq”的研究。该研究利用抗CD3/CD28磁珠刺激人静息态T细胞,并对刺激前后的样本进行单细胞转录组测序(scRNA-seq),整合公共数据从细胞亚群、基因表达、细胞-细胞通讯...
AlekseyV. Belikov. The role of reactive oxygen species and mitochondria in T-cellactivation. (图1) YoshihiroOhue,Hiroyoshi Nishikawa. Regulatory T (Treg) cells in cancer: Can Treg cellsbe a new therapeutic target? Cancer Sci. 2019 Jul;110(7):2080-2089.(图2) 作者:奇 诺 本文首发于“ 解...
[6]Hong J J, Amancha P K, Rogers K, et al. Spatial alterations between CD4(+) T follicular helper, B, and CD8(+) T cells during simian immunodeficiency virus infection: T/B cell homeostasis, activation, and potential mechanism for viral escape. J Immunol, 2012, 188(7): 3247-3256 [...
近日,来自比利时鲁汶大学的Diether Lambrechts团队在Immunity上发表题为CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy in head and neck squamous carcinoma的文章。通过对...
[4] Maes, Michael. T cell activation via the CD40 ligand and transferrin receptor and deficits in T regulatory cells are associated with major depressive disorder and severity of depression. T cell activation via the CD40 ligand and transferrin receptor and deficits in T regulatory cells are ...
近日,明尼苏达大学David Masopust在Nature Immunology上发表了题为CD4+ T cell memory的综述论文,对记忆CD4+ T细胞进行了系统性综述。 图片 记忆CD4+ T细胞的寿命和检测手段 有研究显示,在接种天花疫苗后75年,记忆CD4+ T细胞在体外经抗原特异性肽段的再刺激后仍能产生IFN-γ。麻疹疫苗接种后至少34年、麻腮风疫苗接种...
9. PGK1 regulates CD4+ T cell activation and Th17 cell differentiation in myocarditis patients 最后作者在患者样本上做了一下验证。 作者首先分离了心肌炎患者外周血单个核细胞。 Fig 7A, B:免疫荧光显示PGK1与CD4和IL-17A共定位。 Fig 7C, D:随后作者分离了心肌炎患者外周血CD4T细胞。NG52治疗降低了T细胞...
(signal 2) initiate T-cell activation. These activated naïve CD4+T cells further differentiate into distinct subsets of helper T cells, including TH1, TH2, TH17, Treg, and TFHcells, in different cytokine milieus (signal 3), as defined by their pattern of effector cytokine production and ...