primarily activated CD4 T lymphocytesTöpfer, ANiemöller, MAssenmacher, MGmbh, Miltenyi BiotecGladbach, Bergisch
Approaches that enhance radiation effect may lead to improved clinical outcome and decrease toxicity. Here we investigated whether activated CD4+ T cells (aCD4) can serve as an effective radiosensitizer. CD4+ T cells were activated with anti-CD3 and anti
Costimulator dependence of lymphokine secretion by naive and activated CD4+ T lymphocytes from TCR transgenic mice The role of costimulation in Ag-induced responses of naive and differentiated IL-2 and IL-4-producing CD4+ T cells has been examined using cells from mice expressing a transgenic ...
Pathogen-specific CD4 T cells are activated within a few hours of oral Salmonella infection and are essential for protective immunity. However, CD4 T cells do not participate in bacterial clearance until several weeks after infection, suggesting that Salmonella can inhibit or evade CD4 T cells that...
Using fetal thymic organ cultures (FTOCs), the present study investigated the impact of recirculating T cells on the two major cell populations in the thymus, namely the thymocytes and the TECs. Co-culturing with activated T cells, especially CD4+T cells, had a significant inhibitory effect on...
T cell-mediated responses have been implicated in the development of fibrosis, impaired lymphangiogenesis, and lymphatic dysfunction in secondary lymphedema. Here we show that CD4+ T cells are necessary for lymphedema pathogenesis by utilizing adopt
Killing HIV-infected resting CD4+ T cells early after viral entry before the reverse transcription step would abrogate both abortive and latent infection and would thus help to decrease CD4+ T cell depletion and inflammation, and could affect the size of the latent viral reservoir. It has been ...
BACKGROUND: Methylprednisolone (MP) can affect the survival of CD4 + T lymphocytes and plays an important role in adaptive immune responses; however, its mechanism of action is not clear. Recent studies have shown that toll- like receptors (TLRs) on CD4 + T cells can directly modulate adaptiv...
However, a small proportion of splenic T cells are large activated cells both in specific pathogen-free and antigen-free mice. To further elucidate the effector functions associated with these "naturally" activated CD4+ T cells, we have characterized the expression of various membrane markers, cytok...
P-Selectin pathways are essential to the preferential recruitment of activated CD4+T cells to the colonestimating distancehealthcare accessibilitydriving distancedriving time"Fire … is a highly political phenomenon," explain theauthors of Flammable Cities, an academic survey of urban conflagrations and ...