Banczyk,D.,Kalies,etc.Activated CD4+ T cells enter the splenic T-cell zone and induce autoantibody-producing germinal centers through bystander activation[J].2014,1(1).Banczyk D; Kalies K; Nachbar L;.Activated CD4^+ T cells enter the splenic T-cell zone and induce autoantibody-producing ...
T cell-mediated responses have been implicated in the development of fibrosis, impaired lymphangiogenesis, and lymphatic dysfunction in secondary lymphedema. Here we show that CD4+ T cells are necessary for lymphedema pathogenesis by utilizing adopt
CD4+ T cells mediate hemarthrosis-induced liver impairment Since the joint and the liver are not in direct contact, we next hypothesized that peripheral blood contributes to the crosstalk. Single-cell mass cytometry (CyTOF) was applied to the CD45+ peripheral blood mononuclear cells (PBMCs). U...
BACKGROUND: Methylprednisolone (MP) can affect the survival of CD4 + T lymphocytes and plays an important role in adaptive immune responses; however, its mechanism of action is not clear. Recent studies have shown that toll- like receptors (TLRs) on CD4 + T cells can directly modulate adaptiv...
Two hours after a Vpr-βlam infection assay, the primary non-activated HIV+ CD4+ T cells (blue) from an elite controller (EC) were co-cultured for 30 min with an autologous Gag-specific CD8+ T cell line (green), fixed, and stained for actin with phalloidin (orange) and perforin (red...
CD103 (alphaEbeta7) has been shown to be an excellent marker for identifying in vivo-activated FoxP3(+)CD4(+) regulatory T (Treg) cells. It is unknown whether reinfusion of in vivo-activated donor-type CD103(+) Treg cells from recipient can ameliorate ongoing chronic graft...
(Fig.2B), we observed a notable rise in neutrophil presence within the tumor microenvironment. Conversely, other immune cell types (Fig.2C–H), such as B cells, macrophages, DC cells, CD4+T cells, and CD8+T cells, showed no significant numerical discrepancies, implying that neutrophils act...
assays. The cells can be used as activated cell marker controls with minimal variability across experiments. These cells have been verified to work with commonly tested cell surface, as well as T cell activation markers such as CD3, CD4, CD8, CD25, CD366(TIM3), TIGIT, CD69, CD279 and ...
(Supplementary Fig.1b). Two cell types were used as recipients, HeLa cells ectopically expressing CD4 and human primary CD4+T cells, which are one of the main targets of HIV-1. The data obtained with CD4+HeLa cells are described in Supplementary Note1, as they essentially recapitulate those...
The ZFP36 family of RNA-binding proteins acts post-transcriptionally to repress translation and promote RNA decay. Studies of genes and pathways regulated by the ZFP36 family in CD4+ T cells have focussed largely on cytokines, but their impact on metabol