Dendritic cell (DC)-derived EVs directly enhance the antigen-specific responses of CD4+and CD8+T cells and participate in the activation of NK cells5. EV miRNAs from T cells are transferred into DCs in an antigen-specific manner6. In addition, it has been reported that regulatory T cell-de...
CD28 + subsets; (2) CD8 + cell anti-HIV activity in vitro resides predominantly in the separated CD8 + cell subsets that express HLA-DR or CD28; and (3) in longitudinal studies, CD8 + cell anti-HIV activity decreased as an individual progressed from a healthy state to an AIDS condition...
Our results suggest that there is a dysregulation in T-cell homeostasis in aged mice associated with a decrease in AICD of CD8 + T cells. 展开 关键词: Aging CD8 + T Cells Activation-induced cell death Apoptosis Fas Fas ligand IFN-γ DOI: 10.1016/S0047-6374(01)00279-2 被引量: 51...
1990. Activated CD8 binding to class I protein mediated by the T-cell receptor results in signalling. Nature 346: 187.O'Rourke, A.M., J. Rogers, and M.F. Mescher. 1990. Acti- vated CD8 binding to class I protein mediated by the T-cell receptor results in signaling. Nature (Lond....
T. Fearon, "T-bet-mediated differentiation of the activated CD8+ T cell," Eur J Immunol, vol. 41, no. 1, p. 6066, 2010.Yeo, C. J. & Fearon, D. T. T-bet-mediated differentiation of the activated CD8+ T cell. Eur. J. Immunol. 41, 60-66 (2011)....
FasLmediatedapopto-sis,expressionofCD45/ROasamemorycellmarker,expressionofCD25asactivationmarkersonCD4andCD8Tcellsthroughflowcytometryat48hand5daysofco-culture.ThelevelsofIFN-candTNF-awerestudiedintherespectivesupernatant.Results:AscomparedwithunactivatedPBMCasignificantlyhighpercentageofCD4/CD25+andCD8/CD25...
, and killing of infected cells. immune recognition is induced by hla-i presentation of peptides derived from incoming viral particles, and recognition occurred either following cell-free virus infection or following cell-to-cell spread. cd8 + t cells from hiv controllers mediate more effective ...
After an infection, T cells that carry the CD8 marker are activated and undergo a characteristic kinetic sequence of rapid expansion, subsequent contractio... D Zehn,SY Lee,MJ Bevan - 《Nature》 被引量: 688发表: 2009年 Activated Leukocyte Cell Adhesion Molecule/CD166, a Marker of Tumor Prog...
cytokines and activation marker CD69. In addition it has the aim to find the correlation between each subset and systemic inflammation, to evaluate the migration of specific subsets of T cells towards PsA synovial fluid and to compare the phenotype of CD8+and CD4+T cells in peripheral blood an...
Recently, Wrzesinski et al42 showed that lymphodepletion preferentially induces the expansion of adoptively transferred CD8+ cells, while Rapaport et al43 reported that T cell infusions given after HDC and autoSCT resulted in significantly improved T cell proliferation. Thus, lymphodepletion may enhance...