Human naive CD4+ T cells, as defined by expression of CD45RA and lack of CD45R0, can be activated in vitro using B cells as accessory cells. CD4+CD45RA+ T cells proliferate, as determined by [3H]thymidine or bromodeoxyuridine (BrdU) incorporation, after activation with the superantigen ...
While STAT3 activity is an ever-present feature of IL-6 signaling in CD4+ T cells, prior activation via the T cell antigen receptor limits IL-6’s control of STAT1 in effector and memory populations. Here we found that phosphorylation of STAT1 in response to IL-6 was regulated by the ...
Unlike naive T cells, memory phenotype (CD44(high)) T cells exhibit a high background rate of turnover in vivo. Previous studies showed that the turnover of memory phenotype CD8(+) (but not CD4(+)) cells in vivo can be considerably enhan... DF Tough,X Zhang,J Sprent - 《Journal ...
作者: Shivaprakash Gangappa, Shilpa P. Deshpande, Barry T. Rouse 摘要: Herpetic stromal keratitis (HSK) is an immunopathological lesion involving herpes simplex virus (HSV) infection and CD4+ T cells of the Th1 phenotype, but the nature of the target antigens which drive HSK remains ...
of TRAF6, which augments MALT1 scaffolding function, but not protease activity. Naive CD4+T cells express almost exclusively MALT1B and MALT1A expression is induced by TCR stimulation. We identify hnRNP U as a suppressor of exon7 inclusion. Whereas selective depletion of MALT1A impairs T-cell...
Home/ What Are T Cells? / Naïve CD4+ T Cells: Naïve T Cell Markers and Act...The human adaptive immune system is made up of T and B lymphocytes working together to regulate immune responses to harmful pathogens. T lymphocytes develop in the thymus and mediate cellular immunity. T ...
Helper T Cells T helper cells, or CD4+ cells, are similar to cytotoxic cells but have a wider range of functions. These cells are extremely important to cell immunity because they are required for most adaptive immune responses. T helper cells become activated when presented with antigens and...
Reciprocal activation of CD4+ T cells and Kupffer cells in ischemic reperfusion of the liverT cells are suggested to be involved in the induction of ... A Khandoga,M Hanschen,S Zahler,... 被引量: 0发表: 2008年 Reciprocal activation between CD4+ T cells and Kupffer cells during hepatic ...
All helper T cells recognise foreign protein antigens presented by class II molecules of the major histocompatibility complex (MHC) and express the cell surface molecule CD4. However, not all CD4 T cells behave as helper T cells when assayed for their ability to activate B cells to produce ant...
This cellular heterogeneity further complicates interpretation of immune disease-associated variants. Given the dynamic nature of T cell activation and the heterogeneity of CD4+ T cells, we mapped gene expression regulation using single-cell transcriptomes spanning four time points of CD4+ T cell ...