Ferroptosis是一种受调控的细胞死亡,与传统的细胞凋亡和坏死有明显区别,是由铁依赖性脂质过氧化积累引发的。在细胞形态上,细胞线粒体减少,膜密度增加,嵴减少。然而,细胞核的形态变化尚不清楚。在细胞成分方面,铁死亡是由过度的脂质过氧化和活性氧(ROS)引起的[1]。胱氨酸/谷氨酸反向转运蛋白(System xc-)系统位于细胞...
运输条件:美国大陆的室温;其他地方可能有所不同。 产品活性:Imidazole ketone erastin 是一种有效的,选择性的,代谢稳定的胱氨酸-谷氨酸逆转运蛋白,system xc- 抑制剂和 ferroptosis 活化剂。Imidazole ketone erastin 具有抗肿瘤活性。 体外:咪唑酮erastin (IKE) (0.1 nM-100 μM; 24 h) 通过脂质过氧化和铁死亡...
铁死亡(Ferroptosis):一种由铁依赖性脂质过氧化驱动的细胞死亡形式,从发育到衰老、免疫和癌症都能看到它的身影,其诱导因子可通过不同途径直接或间接影响谷胱甘肽过氧化物酶4(Glutathione Peroxidase 4,GPX4),导致抗氧化能力下降和细胞中脂质活性氧(ROS)积累,最终导致细胞死亡。 铁死亡在细胞形态和功能上与坏死、凋亡、自...
System Xc (a cystine/glutamate antiporter system) is a promising target in cancer cells for ferroptosis induction. The overexpression of system Xc, especially its core subunit xCT, has been reported in several tumors, and these high expression levels were closely related to cancer cell proliferation...
产品活性:Imidazole ketone erastin 是一种有效的,选择性的,代谢稳定的胱氨酸-谷氨酸逆转运蛋白,system xc- 抑制剂和 ferroptosis 活化剂。Imidazole ketone erastin 具有抗肿瘤活性。 体外:咪唑酮erastin (IKE) (0.1 nM-100 μM; 24 h) 通过脂质过氧化和铁死亡有效减少弥漫性大B细胞淋巴瘤 (DLBCL) 细胞数量[1...
The amino acid antiporter system Xc− is important for the synthesis of glutathione (GSH) that functions to prevent lipid peroxidation and protect cells from nonapoptotic, iron-dependent death (i.e., ferroptosis). While the activity of system Xc− of
Expression of system xc−was positively correlated with ERα expression, and predicted the poor outcome of ER+ breast cancer To investigate how ERα regulates ferroptosis in ER+ breast cancer cells, we conducted an analysis of ferroptosis-related genes that are also regulated by estrogen. Examinat...
Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy 2021, Protein and Cell Ferroptosis: mechanisms, biology and role in disease 2021, Nature Reviews Molecular Cell Biology Mechanisms of ferroptosis 2016, Cellular and Molecular Life Sciences Modulation of oxidat...
Ferroptosis is a form of regulated cell death triggered by lipid peroxidation after inhibition of the cystine/glutamate antiporter system Xc–. However, key regulators of system Xc– activity in ferroptosis remain undefined. Here, we show that BECN1 plays a hitherto unsuspected role in promoting fe...
regulation of ROS levels in cancer cells have been identified as an important factor in reducing ferroptosis, a nonapoptotic pathway linked to iron-dependent oxidative cell death5,6. The glutathione system plays a central role in redox homoeostasis and consists of glutathione (GSH), glutathione redu...