Presents a case of a man with schizophrenia who appeared much improved after switching from perphenazine to clozapine, but requested for a change to olanzapine because of his long-standing and deeply held objections to weekly blood testing. Functional improvement with clozapine; Argument for not ...
Henderson DC, Nasrallah RA, Goff DC. Switching from clozapine to olanzapine in treatment-refractory schizophrenia: safety, clinical efficacy, and predictors of response. J Clin Psychiatry. 1998;59(11):585–8. ArticlePubMedCASGoogle Scholar Lee CT, Conde BJ, Mazlan M, et al. Switching to olan...
The specific properties of S-layer proteins from three different Bacillus stearothermophilus strains revealing oblique, square, or hexagonal lattice symmet... M Sára,UB Sleytr - 《Journal of Bacteriology》 被引量: 101发表: 1994年 Clozapine Treatment for Suicidality in Schizophrenia—Correction Errors ...
In before-to-after switch meta-analyses, aripiprazole (1.96 kg, 95% CI 3.07, 0.85, P < .001) and ziprasidone (2.22 kg, 95% CI 3.84, 0.60, P = .007) were associated with weight loss, whereas olanzapine (2.71 kg, 95% CI 1.87, 3.55, P < .001), and clozapine (2.80 kg, 95% ...
Previous research shows that amisulpride (multiple brands) and olanzapine (Zyprexa, Lilly) have similar efficacy in treating first-episode schizophrenia, despite their different receptor binding profiles. Current guidelines recommend that clozapine be offered to patients who have failed to respond to two ...
The atypical antipsychotics (such as clozapine, risperidone, sertindole and olanzapine) offer important advantages over older typical drugs, which are sufficient for many clinicians to consider switching patients from typical to atypical drugs. To do this, typical agents should be withdrawn slowly over...
Second-generation antipsychotics (SGAs), valproate, and sulpiride are related to significant weight gain and risk of metabolic syndrome (MetS). Among SGAs, olanzapine and clozapine are associated with the highest metabolic risk while ziprasidone is among one of the SGAs with the lowest risk. ...
Data were gathered from a treatment algorithm implemented in patients with first-episode schizophrenia that employs two antipsychotic trials at increasing doses before clozapine. Patients were initially treated with either olanzapine or risperidone across three dose ranges, (low, full, high), and in ...
Weigmann H, Hartter S, Maehrlein S, et al. Simultaneous determi- nation of olanzapine, clozapine and demethylated metabolites in serum by on-line column switching high performance liquid chro- matography. J Chromatogr B 2001;759:63-71.
ClozapineOlanzapineQuetiapineRisperidoneSchizophreniatreatmentZiprasidoneThe introduction of second-generation antipsychotics represents an important advance in the treatment of schizophrenia. Although these drugs are generally very effective, not all patients respond in the same way. Partial response with persistent...