Presents a case of a man with schizophrenia who appeared much improved after switching from perphenazine to clozapine, but requested for a change to olanzapine because of his long-standing and deeply held objections to weekly blood testing. Functional improvement with clozapine; Argument for not ...
Dossenbach MRK, Beuzen JN, Avnon M, et al. The effectiveness of olanzapine in treatment-refractory schizophrenia when patients are nonresponsive to or unable to tolerate clozapine. Clin Ther. 2000;22(9):1021–34. Faries DE, Ascher-Svanum H, Nyhuis AW, Kinon BJ. Switching from risperidone...
OBJECTIVE: After rapid discontinuation of clozapine treatment rebound psychosis have been reported. Preexposure of D (2) receptors to clozapine may alter their affinity to endogenous dopamine. Clozapine withdrawal may also lead dysfunctional NMDA-receptors to cause dopamine release in the striatum. METHOD...
Clozapine has been shown to be effective in about one third of this popu... RR Conley,CA Tamminga,DL Kelly,... - 《Biol Psychiatry》 被引量: 219发表: 1999年 Olanzapine monotherapy and olanzapine combination therapy in the treatment of mania: 12-week results from the European Mania in ...
According to a recommendation from the American Psychiatric Association, patients are maintained on an adequate dosage of an antipsychotic for 4-6 weeks before switching to another agent with an exception for clozapine, which should be continued for 3 months. The success of switching from one ...
In before-to-after switch meta-analyses, aripiprazole (1.96 kg, 95% CI 3.07, 0.85, P < .001) and ziprasidone (2.22 kg, 95% CI 3.84, 0.60, P = .007) were associated with weight loss, whereas olanzapine (2.71 kg, 95% CI 1.87, 3.55, P < .001), and clozapine (2.80 kg, 95% ...
The atypical antipsychotics (such as clozapine, risperidone, sertindole and olanzapine) offer important advantages over older typical drugs, which are sufficient for many clinicians to consider switching patients from typical to atypical drugs. To do this, typical agents should be withdrawn slowly over...
Data were gathered from a treatment algorithm implemented in patients with first-episode schizophrenia that employs two antipsychotic trials at increasing doses before clozapine. Patients were initially treated with either olanzapine or risperidone across three dose ranges, (low, full, high), and in ...
ClozapineOlanzapineQuetiapineRisperidoneSchizophreniatreatmentZiprasidoneThe introduction of second-generation antipsychotics represents an important advance in the treatment of schizophrenia. Although these drugs are generally very effective, not all patients respond in the same way. Partial response with persistent...
Weigmann H, Hartter S, Maehrlein S, et al. Simultaneous determi- nation of olanzapine, clozapine and demethylated metabolites in serum by on-line column switching high performance liquid chro- matography. J Chromatogr B 2001;759:63-71.