Clozapine Cobicistat Codeine Crizotinib Cyclobenzaprine Dabrafenib Daridorexant Dasatinib Degarelix Delamanid Desipramine Deslorelin Deutetrabenazine Dexmedetomidine Diacetylmorphine Diazepam Dichloralphenazone Difenoxin Dihydrocodeine Diphenhydramine Diphenoxylate Disopyramide Dofetilide Dolasetron Domperidone Donepezil Doxepin...
Clozapine Cobicistat Codeine Crizotinib Cyclobenzaprine Dabrafenib Daridorexant Dasatinib Degarelix Delamanid Desipramine Deslorelin Deutetrabenazine Dexmedetomidine Diacetylmorphine Diazepam Dichloralphenazone Difenoxin Dihydrocodeine Diphenhydramine Diphenoxylate
To date, there is no biomarker for a high risk of atypical antipsychotic-generated IR that could be detected simply through blood analysis, especially for olanzapine and clozapine. We addressed the role of miRNA-containing circulating EVs as mediators of individual insulin sensitivity responsiveness ...
The atypical antipsychotics clozapine and olanzapine promote down-regulation and display functional selectivity at human 5-HT7 receptors. Br J Pharmacol; e-pub ahead of print 17 Apr 2015. doi: 10.1111/bph.13169.Andressen KW, Manfra O, Brevik CH, Ulsund AH, Vanhoenacker P, Levy FO, K...
of olanzapine and clozapine to induce EPS. One possible explanation for this apparent anomaly is that D2occupancy rates alone do not determine propensity to cause EPS. Indeed, it has been suggested that the difference between antipsychotic drugs which can elicit parkinsonism (e.g. haloperidol, chlo...
addition, the antipsychotic treatment partially restored the deficit of adult neurogenesis and neuronal maturation in both rodent models and in the human, the latter according to postmortem tissues13,14, indicating enhanced neural plasticity. Taken together, these studies indicate the potential of ...
32 patients with a history of clozapine related neutropenia or a lack of granulocyte had no neutropenia after olanzapine treatment, and a common neutropenia was found in combination with olanzapine and sodium valproate. There is limited information on the combination of lithium sa...
In addition, some effective antipsychotic drugs, such as clozapine, potentiate NMDA-receptor mediated neurotransmission (Arvanov et al., 1997) and increase glutamate concentrations in serum (Goff et al., 1996, Evins et al., 1997) and specific brain areas (Daly and Moghaddam, 1993, Yamamoto ...
In addition, we found that LXRα overexpression compromised the effect of metformin on PCSK9 levels and intracellular lipid droplet formation. Taken together, our findings suggest that olanzapine enhances hepatic PCSK9 expression by upregulating LXRα, thereby increasing FAS and SCD1 expression as well...
This study found that clozapine had clear advantages over haloperidol with regard to efficacy in reducing both positive and negative symptoms. However, it also highlighted clozapine's potential for significant toxicity, which appears heightened in the pediatric population. The limited number of rigorous ...