Tollefson GD, Dellva MA, Mattler CA, Kane JM, Wirshing DA, Kinon BJ. Controlled double-blind investigation of the clozapine discontinuation symptoms with conversion to either olanzapine or placebo. The Collaborative Crossover Study Group. J Clin Psychopharmacol 1999;19(5):435-43....
Gardner et al., “A Comparison of the Covalent Binding of Clozapine and Olanzapine to Human Neutrophils In Vitro and In Vivo,” Mol. Pharmacol., 1998, vol. 53, pp. 999-1008. Liu et al., “Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly...
We further confirmed that the animals had learned to recognize specifically the interoceptive effects of clozapine and not simply any drug-induced state by testing several compounds with varying degrees of similarity to clozapine for their capacity to substitute for the clozapine stimulus. Olanzapine, wh...
Pharmacological evaluation of a modified open-field test sensitive to anxiolytic drugs Pharmacol. Biochem. Behav., 59 (1998), pp. 677-683 Google Scholar [13] A. Mead, M. Li, S. Kapur Clozapine and olanzapine exhibit an intrinsic anxiolytic property in two conditioned fear paradigms: contrast ...
(CKB) subunit has been shown to be a robust biomarker for acute myocardial infarction,28an interesting observation given the elevated risk of myocarditis following clozapine exposure.29Of note, elevated levels of serum CKM have been reported after both clozapine30and olanzapine treatment.31CKM is ...
conversion to NDMC (Weiner et al, 2004). As clozapine is a cholinergic antagonist (Bolden et al, 1991) and NDMC is claimed to be a cholinergic agonist, the overall effects when NDMC is generated in a patient on clozapine would depend on the ratio of NDMC to clozapine. It has been ...