The neuroactive steroid allopregnanolone is a potent γ-aminobutyric acid type A (GABAA) receptor modulator with anxiolytic and anticonvulsant effects. Olanzapine and clozapine also have anxiolytic-like effects in behavioral models. We therefore postulated that olanzapine and clozapine would elevate allopr...
Clozapine in Combination With Olanzapine Long-Acting Injection: The Intersection of Treatment-Resistant Schizophrenia and Poor Medication Adherence—A Case Reportdoi:10.1097/JCP.0000000000001746Phillipa Louise,BrothwoodMina,HusainJessica,PinsonEbenezer,Oloyede...
To understand the mechanism of the clinical efficacy of olanzapine and fluoxetine combination therapy for treatment-resistant depression (TRD), we studied ... WZ Md,D Ph. - 《Neuropsychopharmacology》 被引量: 400发表: 2000年 Clozapine and quetiapine acutely reduce glucagon-like peptide-1 production...
Clozapine, Olanzapine, Risperidone, and Haloperidol in the Treatment of Patients with Chronic... Use of clozapine to treat schizophrenia; Results of risperidone treatment in patients with refractory schizophrenia; Variation in the inclusion criteria and ... Volavka,Jan,Czobor,... - 《American Journ...
The acute and long-term effect of olanzapine compared with placebo and haloperidol on serum prolactin concentration Prolactin elevation is both a common and a persistent event with the currently marketed antipsychotics, excluding clozapine. Elevations have been associate... B Jones,AMK Crawford,CM Beasl...
Efficacy of clozapine for this indication has been established in a multicenter, randomized, open-label clinical study (the International Suicide Prevention Trial [InterSePT]) of 2 years' duration comparing clozapine and olanzapine in patients with schizophrenia (62%) or schizoaffective disorder (38...
Current evidence addressing this question does not support this position, although the limited data available and methodological issues preclude a firm conclusion. Practical issues related to clozapine use, in combination with the robust response reported for other agents when used as first-line ...
Furthermore, comparisons of the effects of clozapine therapy on suicidal behavior and the effects produced by using other atypical antipsychotic drugs, for example, quetiapine fumarate, olanzapine, risperidone, or ziprasidone hydrochloride, have not been performed. Because of their potential advantages ...
10.Efficacy and safety of clozapine or olanzapine in combination with other antischizophrenic drugs氯氮平、奥氮平与其他抗精神分裂症药物联用的疗效与安全性 11.Effects of olanzapine and clozapine on cognitive function in chronic schizophrenia奥氮平和氯氮平对慢性精神分裂症的认知功能的影响 ...
patients with schizophrenia that looked at the impact of clozapine versus other antipsychotics. They reviewed information on 1,952 patients enrolled in eightclinical trialsthat included 922 people treated with clozapine and the remainder with other first-line antipsychotics, like risperidone and olanzapine...