The drug is structurally similar to clozapine.Uses for OlanzapineSchizophreniaOrally (as olanzapine) and IM (as the long-acting olanzapine pamoate ester) for the acute and maintenance treatment of schizophrenia.IM (as short-acting olanzapine) for management of acute agitation in patients with schizophr...
The receptor binding affinity profiles of the atypical and typical antipsychotic agents differ from each other (table I). Olanzapine has lower affinity for α1-adrenergic receptors than clozapine and risperidone, higher affinity for histaminergic H1receptors than haloperidol and risperidone, and low affin...
There is insufficient evidence to consider high-dose olanzapine equivalent to clozapine when clozapine is not contraindicated. Overall, high-dose olanzapine was well tolerated, with no serious side effects. Registration: This systematic review was preregistered with PROSPERO [CRD42022312817].doi:10.1177/...
Cite this: Long-Acting Injected Olanzapine Shows Equivalent Efficacy to Short-Acting Oral Formulation - Medscape - Nov 10, 2009.Recommendations Europe Approves Neutropenia and Schizophrenia Treatments news Clozapine Underutilized in Black Patients With Schizophrenia news Strategic Approaches for Managed Ca...
Nearly half of the participants took less than 300-mg chlorpromazine (CPZ) equivalent dose, 50.9%. About 46.9% of the respondents used at least one substance, and a substantial proportion engaged in khat (Catha edulis) use, 39.9%. Hospitalization was prevalent, 94.1%. The majority of patients...
Gender differences in neuroleptic nonresponsive clozapine-treated schizophrenics. Gender differences in neuroleptic-refractory chronic schizophrenic disorder patients were examined to determine whether a superior or equivalent antipsycho... S Szymanski,J Lieberman,S Pollack,... - 《Biol Psychiatry》 被引量...
Furthermore, to a similar magnitude as that of clozapine, idazoxan enhanced the effects of both raclopride and risperidone on prefrontal NMDA receptor-mediated transmission, an effect that has been shown to be dopamine-dependent and executed through the dopamine D1 receptor (Chen and Yang, 2002;...
One US dollar (USD) was equivalent to 110 Japanese yen. This study was approved by the Institutional Review Board of the University of Tokyo (approval number 3501- 5; May 19, 2021). The review board waived the requirement for patient-informed consent because of the use of anony- mous ...
Clozapine and olanzapine (OLA) are among the most concerning AAPs in terms of MetS risk [27]. OLA is the fourth most commonly prescribed AAP, accounting for ~10% of all AAP prescriptions. Importantly, type 2 diabetes (T2D) is not always strictly linked to adiposity (weight gain), and 25...
In addition to Olanzapine, it has been reported that Clozapine also induces metabolic disorders through a muscarinic M3 receptor mechanism [32]. Further studies are important to investigate whether Clozapine-induced metabolic disorders are also mediated by Alk signaling, and can be attenuated by co...