There is insufficient evidence to consider high-dose olanzapine equivalent to clozapine when clozapine is not contraindicated. Overall, high-dose olanzapine was well tolerated, with no serious side effects. Registration: This systematic review was preregistered with PROSPERO [CRD42022312817].doi:10.1177/...
Cite this: Long-Acting Injected Olanzapine Shows Equivalent Efficacy to Short-Acting Oral Formulation - Medscape - Nov 10, 2009.Recommendations Europe Approves Neutropenia and Schizophrenia Treatments news Clozapine Underutilized in Black Patients With Schizophrenia news Strategic Approaches for Managed Ca...
The drug is structurally similar to clozapine.Uses for OlanzapineSchizophreniaOrally (as olanzapine) and IM (as the long-acting olanzapine pamoate ester) for the acute and maintenance treatment of schizophrenia.IM (as short-acting olanzapine) for management of acute agitation in patients with schizophr...
Furthermore, to a similar magnitude as that of clozapine, idazoxan enhanced the effects of both raclopride and risperidone on prefrontal NMDA receptor-mediated transmission, an effect that has been shown to be dopamine-dependent and executed through the dopamine D1 receptor (Chen and Yang, 2002;...
atypical antipsychotic < or = 14 days prior to study entry (risperidone, olanzapine, quetiapine, or clozapine; 200-600 mg/d chlorpromazine-equivalent dos... Y Levkovitz,S Mendlovich,S Riwkes,... - 《Journal of Clinical Psychiatry》 被引量: 485发表: 2010年 Obesity and Related Metabolic Abno...
Regarding all-cause discontinuation, clozapine, olanzapine, and risperidone were superior to several other second-generation antipsychotics. Similarly for relapse prevention, olanzapine was found to be superior to chlorpromazine and haloperidol [20]. Schizophrenia subjects are reported to have a higher ...
expectation that higher rates would be found for subjects treated with risperidone was based on our own and others' case reports, as well as the evidence that risperidone produces EPS in a dose-related manner, and based on the similarity of olanzapine's receptor profile to that of clozapine. ...
Both quetiapine and the SGA prototype – clozapine – have low affinities for the D2 receptor and do not reach receptor occupancies corresponding to the therapeutic window at clinical doses [31, 32]. The inferiority of haloperidol and risperidone found in the EUFEST sample and our sample, ...
Clinical findings suggest that many atypical antipsychotics, particularly olanzapine and clozapine, are associated with weight gain, glucose abnormality, insulin resistance, and hyperlipidemia which can increase the risk of developing cancer, along with metabolic and cardiovascular diseases. Data from an ...
In addition to Olanzapine, it has been reported that Clozapine also induces metabolic disorders through a muscarinic M3 receptor mechanism [32]. Further studies are important to investigate whether Clozapine-induced metabolic disorders are also mediated by Alk signaling, and can be attenuated by co...