A long-acting injectable formulation of olanzapine is equivalent to the short-acting oral formulation that is on the market, and allows for administration only once every 2 to 4 weeks.
The drug is structurally similar to clozapine.Uses for OlanzapineSchizophreniaOrally (as olanzapine) and IM (as the long-acting olanzapine pamoate ester) for the acute and maintenance treatment of schizophrenia.IM (as short-acting olanzapine) for management of acute agitation in patients with schizophr...
Gender differences in neuroleptic nonresponsive clozapine-treated schizophrenics. Gender differences in neuroleptic-refractory chronic schizophrenic disorder patients were examined to determine whether a superior or equivalent antipsycho... S Szymanski,J Lieberman,S Pollack,... - 《Biol Psychiatry》 被引量...
Furthermore, to a similar magnitude as that of clozapine, idazoxan enhanced the effects of both raclopride and risperidone on prefrontal NMDA receptor-mediated transmission, an effect that has been shown to be dopamine-dependent and executed through the dopamine D1 receptor (Chen and Yang, 2002;...
Clozapine, iloperidone, quetiapine, olanzapine, risperidone and ziprasidone represent the new generation of antipsychotic drugs, successors to the typical ... J. Ichikawa… - 《European Archives of Psychiatry & Clinical Neuroscience》 被引量: 231发表: 1999年 Antipsychotic medication: effects on regulat...
Regarding all-cause discontinuation, clozapine, olanzapine, and risperidone were superior to several other second-generation antipsychotics. Similarly for relapse prevention, olanzapine was found to be superior to chlorpromazine and haloperidol [20]. Schizophrenia subjects are reported to have a higher ...
Olanzapine shows mesolimbic sensitivity, blocks conditioned avoidance at lower doses than those inducing catalepsy, substitutes for clozapine in a drug discrimination assay, produces a modest rise in prolactin, produces few extrapyramidal side effects, and reduces positive and negative symptoms of schizophr...
expectation that higher rates would be found for subjects treated with risperidone was based on our own and others' case reports, as well as the evidence that risperidone produces EPS in a dose-related manner, and based on the similarity of olanzapine's receptor profile to that of clozapine. ...
or current; current suicidal ideation per investigator’s opinion; treatment with electroconvulsive therapy or vagus nerve stimulation within the current episode; treatment with clozapine or a monoamine oxidase inhibitor⩽14 days before visit 1; or with remoxipride within 6 months prior to visit 2....
clozapine and olanzapine have been linked to excessive Exclusion criteria of the study included: (i) treatment weight gain, dyslipidemia, hypertension and develop- with study drugs (olanzapine, VPA, Li) during three ment of metabolic syndrome (MetS) [1]. Weight gain is months prior to the ...