HUMAN-IMMUNODEFICIENCY-VIRUSELECTRON TOMOGRAPHYHIV-1 GP41NEUTRALIZING ANTIBODIESGLYCOPROTEIN TRIMERSATOMIC-STRUCTURETYPE-1 MATRIXGP120 COREFUSIONINFECTIVITYEnvelope glycoprotein (Env) spikes on AIDS retroviruses initiate infection of host cells and are therefore targets for vaccine development. Though crystal ...
HIV (Human Immunodeficiency Virus) is a virus which targets the immune system of a person. With time, this HIV weakens and eventually damages the immune system of the individual. The body starts to lose the ability to defend itself against germs, bacteri
AIDS (Acquired Immune Deficiency Syndrome)was first, described as a new disease of humans in 1981. The origins of the disease are controversial. AIDS is caused by a retrovirus, a type of virus which rarely attacks human cells. The first virus of this type recorded in humans is reponsible fo...
V1/V2 of the gp120 component of the viral spike is critical to this evasion. Localized by electron microscopy to a membrane- distal 'cap'2–5, which holds the spike in a neutralization-resistant con- formation, V1/V2 is not essential for entry: its removal, however, renders the virus ...
a combination ofnuclear magnetic resonanceand cryoEM, which are standardstructural biologytools, to see both the overall shape and the atomic details of capsid protein (CA) assembly. It takes about 1,500 copies of CA to make the coat, or capsid, that surrounds the genome of the AIDS virus...
2) AIDS [英][eɪdz] [美][edz] 艾滋病病人 1. Analysis of the Anti-Virus Treatment(ART) of 8 AIDS Patients in Ji nan City; 济南市8例艾滋病病人抗病毒治疗情况分析 2. Investigation on the causes of HIV/AIDS lost to follow up in hospital HIV感染者/艾滋病病人在医院失访原因调查 ...
Mutations can directly impair enzymatic activity or perturb interfaces central to intrinsic folding or extrinsic interactions essential for crafting protein assemblies of virus and viral-host complexes. Auxiliary mutations, which induce compensatory structural and functional changes, can stabilize a mutant ...
Viruses cause a number of diseases in the organisms they infect. Human infections and diseases caused by viruses includeEbolafever, chicken pox, measles, influenza, HIV/AIDS, and herpes. Vaccines have been effective at preventing some types of viral infections, such as small pox, in humans. The...
Scientists say they havedecoded1the entiregenetic2content of the HIV-1 virus, a key source of Aids infection. 科学家称他们已经解码了整个HIV-1病毒的基因内容,这是一个艾滋病传染的关键因素。 The team hope their work will pave the way to new treatments ...
Complete dissociation of the HIV-1 gp41 ectodomain and membrane proximal regions upon phospholipid binding The envelope glycoprotein gp41 mediates the process of membrane fusion that enables entry of the HIV-1 virus into the host cell. Strong lipid affinity of t... J Roche,JM Louis,A Aniana,...