Variable regions 1 and 2 (V1/V2) of human immunodeficiency virus-1 (HIV-1) gp120 envelope glycoprotein are critical for viral evasion of antibody neutralization, and are themselves protected by extraordinary sequence diversity and N-linked glycosylation. Human antibodies such as PG9 nonetheless enga...
Fine structure of human immunodeficiency virus (HIV), immunolocalization of structural proteins and virus-cell relation. Micron Microsc. 19:41-60.Gelderblom,HR,?zel,M,Hausmann,EHS,Winkel,T,Pauli,G,Koch,MA.Fine structure of human immunodeficiency virus (HIV), immunolocalization of structural proteins...
Aichi virus (AiV), an unusual and poorly characterized picornavirus, classified in the genus Kobuvirus, can cause severe gastroenteritis and deaths in children below the age of five years, especially in developing countries1,2. The seroprevalence of AiV is approximately 60% in children under the ...
Doolittle, R.E, Hunkapiller, M.W., Hood, L.E., Devare, S.G., Robbins, K.C., Aaronson, S.A. and Antoniades, H.N.: Simian sarcoma virus oncogene, v-sis, is derived from the gene (or genes) encoding a platelet derived growth factor. Science221: 275–277, 1983. ArticlePubMedC...
HIV (Human Immunodeficiency Virus) is a virus which targets the immune system of a person. With time, this HIV weakens and eventually damages the immune system of the individual. The body starts to lose the ability to defend itself against germs, bacteri
infectivityofthesevirusesismostly dependentontheenvelope.Themostwell- knownexamplesofenvelopedvirusesarethe influenzavirus,HepatitisCandHIV. Complex Thesevirusstructureshaveacombinationoficosahedral andhelicalshapeandmayhaveacomplexouterwallor head-tailmorphology.Thehead-tailmorphologystructure isuniquetovirusesthatonly...
protein asymmetry; HIV-2 structural asymmetry; residue accessibility; protein flexibility; structural alphabet1. Introduction The human immunodeficiency virus of type 1 (HIV-1) and type 2 (HIV-2) are two etiological causative agents of AIDS (acquired immune deficiency syndrome). HIV-1 is observed ...
We report the 2.7 Å resolution structure of a chimeric rhinovirus, MN-III-2, that displays part of the HIV-1 gp120 V3 loop and elicits HIV-neutralizing antibodies. The V3 loop insert is dominated by two type I β turns. The structures of two adjacent tripeptides resemble those of anal...
Molecular modeling and two-dimensional NMR techniques enable us to identify structural features in the third variable region (V3) loop of the human immunodeficiency virus (HIV) surface glycoprotein gp120, in particular the principal neutralizing determinant (PND), that remain conserved despite the seque...
The entry of human immunodeficiency virus (HIV) into cells requires the sequential interaction of the viral exterior envelope glycoprotein, gp120, with the CD4 glycoprotein and a chemokine receptor on the cell surface. These interactions initiate a fusion of the viral and cellular membranes. Although...