The structure of HIV-1 reverse transcriptase complexed with 9-chloro- TIBO: lessons for inhibitor design. Structure 1995, 3, 915-926.Ren, J., R. Esnouf, A. Hopkins, C. Ross, Y. Jones, D. Stammers, and D. Stuart. 1995. The structure of HIV-1 reverse transcriptase complexed with 9...
A regular three-dimensional structure can be formed from repeating subunits using either helical symmetry or icosahedral symmetry principles. In the case of the smallest viruses, the final structure is simple and quite regular. Larger viruses with more proteins at their disposal can build more ...
Structure and function of retroviral integrase Article 09 July 2021 The structural basis of herpesvirus entry Article 21 October 2020 References Gao, F. et al. Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes. Nature 397, 436–441 (1999). Article CAS PubMed Google Scholar Korb...
两者的主要区别在于Ⅰ型含有___,而Ⅱ型含___。另外,vpr和nef与其他基因的关系也不同,HIV-Ⅰ的vpr与vif相互重叠,而nef与env不重叠;HIV-Ⅱ的vpr与vif不重叠,而nef与env相互重叠。相关知识点: 试题来源: 解析 vpu vpx vpu vpx 反馈 收藏
The envelope protein of human immunodeficiency virus-1 (HIV-1) and its fusion peptide are essential for cell entry and vaccine design. Here, we describe the 3.9-Å resolution structure of an envelope protein trimer from a very early transmitted founder
We report the structure of HIV-1 reverse transcriptase (RT) complexed with the nonnucleoside inhibitor TIBO R 86183 at 3.0 A resolution. Comparing this structure with those of complexes of HIV-1 RT/alpha-APA R 95845 and HIV-1 RT/nevirapine provides a basis for understanding the nature of no...
Here, we review the structures of immature and mature HIV virions, focusing on recent studies that have defined the global organization of the immature Gag lattice, identified sites likely to undergo conformational changes during maturation, revealed the molecular structure of the mature capsid lattice...
Superimposed on the concentric circles linking these concepts is the coiled structure of the double helix. The double helix is used to represent humanity and enlightened progression as well as to symbolize scientific understanding that may help us to advance beyond fear. Storey created this image ...
the structure of the Tat protein and its function as a secreted factor. To this end we will summarize some of the exogenous functions of Tat that have been implicated in HIV-1 pathogenesis and the impact of structural variations and viral subtype variants of Tat on those functions. Finally, ...
The structure of 1 was determined by extensive 1D and 2D spectroscopic analyses. Acetylation of 1 yielded the monoacetylated derivative 2-(4',8'-dimethylnona-3'E,7'-dienyl)-8-acetyl-2,6-dimethyl-2H-chromene (6). Compounds 1–6 exhibited various levels of cytotoxic, antibacterial, and anti...