Definition The HIV-1 particle, or virion, transmits the genetic information of the virus from one host cell to the next. There are two morphologically distinct forms of the virion, called "immature" and "mature." The immature virion is the form that assembles and initiates budding at the ...
In the mature phase, the researchers found that IP6 interacts at a site that is revealed after the virus particle cuts away from the cell. At that point, an entirely new lattice develops, made of different proteins than the immature lattice. The findings open the door to possible new therap...
et al. Probability analysis of variational crystallization and its application to gp120, the exterior envelope glycoprotein of type 1 human immunodeficiency virus (HIV-1). J. Biol. Chem. 274, 4115–4123 (1999) Article PubMed CAS Google Scholar Huang, C. C. et al. Structure of a V3-...
Structure-activity relationships of HIV-1 PR inhibitors containing AHPBA 来自 NCBI 喜欢 0 阅读量: 23 作者:M Sakurai,S Higashida,M Sugano,T Komai,Y Yabe 摘要: A series of Human Immunodeficiency Virus type-1 protease (HIV-1 PR) inhibitors that contain 3-amino-2-hydroxy-4-phenylbutanoic acid...
While the mutagenesis of residues in the MHR will impair virus infectivity, the precise solution structure and function of the MHR is not known. To aid the structure/function characterization of the MHR, the structures of synthetic peptides encompassing the MHR of the human immunodeficiency virus ...
Overall structure of the Vpr/hHR23A complex The NMR solution structure of the linked Vpr1-79–L-hHR23A223–363complex (Fig.1b–d) was calculated on the basis of 7650 NOE-derived distance constraints, including 81 Vpr/XPCB and 257 Vpr/UBA2 intermolecular distance constraints, and 330 dihedral...
The human immunodeficiency virus type 1 (HIV-1) trans-activator of transcription protein Tat is an important factor in viral pathogenesis. In addition to its function as the key trans-activator of viral transcription, Tat is also secreted by the infected
The reverse transcriptase (RT) of human immunodeficiency virus (HIV) is the multifunctional enzyme responsible for the conversion of the single-stranded viral RNA genome into double-stranded DNA (dsDNA) that is integrated into the host genome by the viral enzyme integrase. RT has two enzymatic ...
Human immunodeficiency virus type 1 (HIV-1) is an RNA virus that is prone to high rates of mutation. While the disease is managed with current antiretroviral therapies, drugs with a new mode of action are needed. A strategy towards this goal is aimed at targeting the native three-...
Scientists say they havedecoded1the entiregenetic2content of the HIV-1 virus, a key source of Aids infection. 科学家称他们已经解码了整个HIV-1病毒的基因内容,这是一个艾滋病传染的关键因素。 The team hope their work will pave the way to new treatments ...