Structure of HIV genome 'decoded' HIV病毒被“解码” Scientists say they havedecoded1the entiregenetic2content of the HIV-1 virus, a key source of Aids infection. 科学家称他们已经解码了整个HIV-1病毒的基因内容,这是一个艾滋病传染的关键因素。 The team hope their work will pave the way to new...
The article reports that British and German research scientists have studied the three dimensional structure of HIV. The scientists took images of virus particles at different orientations and used powerful computer programs to combine the images. The varied structures and share components of the ...
HIV (Human Immunodeficiency Virus) is a virus which targets the immune system of a person. With time, this HIV weakens and eventually damages the immune system of the individual. The body starts to lose the ability to defend itself against germs, bacteri
Virus particles, called virions, contain the viral genome encapsidated in a protein coat. The function of the coat is to protect the genome of the virus in the extracellular environment as well as to bind to a new host cell and introduce the genome into it. Viral genomes are small and ...
A University of Alabama at Birmingham team led by Jamil Saad, Ph.D., has solved the last unknown protein structure of HIV-1, the retrovirus that can cause AIDS. Knowledge of this structure, called the cytoplasmic tail of gp41protein, will help researchers further understand how the virus inf...
(CRL4DCAF1). HIV-1 Vpr also binds to the multi-domain protein hHR23A, which interacts with the nucleotide excision repair protein XPC and shuttles ubiquitinated proteins to the proteasome. Here, we report the atomic resolution structure of Vpr in complex with the C-terminal half of hHR23A, ...
Influenza A viruses (IAVs) constitute a major threat to human health. The IAV genome consists of eight single-stranded viral RNA segments contained in separate viral ribonucleoprotein (vRNP) complexes that are packaged together into a single virus partic
Crystal Structure of HIV-1 gp41 Including Both Fusion Peptide and Membrane Proximal External Regions The HIV-1 envelope glycoprotein (Env) composed of the receptor binding domain gp120 and the fusion protein subunit gp41 catalyzes virus entry and is a majo... V Buzon,G Natrajan,D Schibli,....
AIDS (Acquired Immune Deficiency Syndrome)was first, described as a new disease of humans in 1981. The origins of the disease are controversial. AIDS is caused by a retrovirus, a type of virus which rarely attacks human cells. The first virus of this type recorded in humans is reponsible fo...
The HIV-1 surface glycoprotein gp120 binds CD4 in the initial state of virus-cell fusion. The extensive glycosylation of gp120 has thus far precluded definition of its structure by crystallographic methods. As an initial approach to a gp120 structure, the surface topology was mapped using antibod...