We further determined the structure of simian immunodeficiency virus (SIV) Nefharboring this region, demonstrating similar C-terminal 伪-helix, which may contribute to AP-1 binding for MHC-I downregulation. These results provide insights into the distinct pathogenesis of HIV-2 infection....
"More generally, if we can unpick the structures then we can compare the systems of different viruses and gain new understanding of how they work." Keith Alcorn of the HIV information service NAM added: "Encouraging the virus to mutate is not a new idea, but it is one of a number of ...
Virus particles, called virions, contain the viral genome encapsidated in a protein coat. The function of the coat is to protect the genome of the virus in the extracellular environment as well as to bind to a new host cell and introduce the genome into it. Viral genomes are small and ...
Getah virus (GETV), a member of the genusalphavirus, is a mosquito-borne pathogen that can cause pyrexia and reproductive losses in animals. Although antibodies to GETV have been found in over 10% of healthy people, there are no reports of clinical symptoms associated with GETV. The biolo...
The envelope protein of human immunodeficiency virus-1 (HIV-1) and its fusion peptide are essential for cell entry and vaccine design. Here, we describe the 3.9-Å resolution structure of an envelope protein trimer from a very early transmitted founder virus (CRF01_AE T/F100) complexed with...
HIV-1 protein structure stained and viewed under an electron microscope. Credit: Robert Dick New research provides details of how the structure of the HIV-1 virus is assembled, findings that offer potential new targets for treatment. The study, authored by a multi-institutional team led by Corne...
ofEasternEuropePWIDco-infectionEstonia is experiencing the new Eastern Europe human immunodeficiency virus (HIV) epidemic, with the highest incidence of new infections in the EU. We describe demographic changes, HIV-related laboratory parameters and co-infections during the concentrated HIV epidemic using...
infectivityofthesevirusesismostly dependentontheenvelope.Themostwell- knownexamplesofenvelopedvirusesarethe influenzavirus,HepatitisCandHIV. Complex Thesevirusstructureshaveacombinationoficosahedral andhelicalshapeandmayhaveacomplexouterwallor head-tailmorphology.Thehead-tailmorphologystructure ...
Influenza A viruses (IAVs) constitute a major threat to human health. The IAV genome consists of eight single-stranded viral RNA segments contained in separate viral ribonucleoprotein (vRNP) complexes that are packaged together into a single virus partic
Furin cleavage of the HIV envelope glycoprotein is an essential step for cell entry that enables formation of well-folded, native-like glycosylated trimers, releases constraints on the fusion peptide, and limits enzymatic processing of the N-glycan shield. Here, we show that a cleavage-independent...