4A). Although both IRF3 and NF-kB were activated by STING-TBK1, subsequent western blot demonstrated that PD-L1 was activated by NF-kB (Fig. 4B) but not IRF3 (Fig. 4C). Moreover, two binding sites of NF-kB in the proximal region of PD-L1 promoter were predicted by bioinformatic ...
本研究发现CD11b激动剂(GB1275)通过同时抑制NF-kB信号和激活干扰素基因表达来改变肿瘤相关巨噬细胞(TAM)表型,间接增强T细胞免疫。NF-kB信号的抑制涉及p65的泛素化降解。另外,通过诱导STING/STAT1途径促进干扰素基因表达。GB1275可上调GZMB、Ki67、CXCL10和CXCL11的表达。I期临床研究( NTC04060342)显示,无论是单药还是...