In the current study, we demonstrated that upregulated TGF-beta may promote epithelial-mesenchymal transition (EMT) through STAT3 activation. In addition, we explored the contributions of STAT3 to HNSCC with a specific focus on its transcriptional regulation and its interaction with the long non...
应用AG490治疗后,TGF-β1的表达下降,说明JAK-STAT信号通路的特异性抑制剂AG490可以抑制JAK信号通路的激活,拮抗TGF-β1的表达,从而阻止肾组织的进一步损伤。 综上所述,AG490可能通过TGF-β1来阻断JAK/STAT3信号通路的激活,进而抑制创伤性休克肾损伤的发展,JAK/STAT3信号通路的激活有可能成为治疗创伤性休克肾损伤的一个...
7. =Wang, H. et al. TGF-beta1-induced epithelial-mesenchymal transition in lung cancer cells involves upregulation of miR-9 and downregulation of its target, E-cadherin. Cell Mol. Biol. Lett. 22, 22 (2017). 8....
STAT3 integrates cooperative Ras and TGF-beta signals that induce Snail expression Oncogene, 35 (2016), pp. 1049-1057 CrossrefView in ScopusGoogle Scholar 45 S. Lamouille, J. Xu, R. Derynck Molecular mechanisms of epithelial-mesenchymal transition Nat. Rev. Mol. Cell Biol, 15 (2014), pp...
What’s more, certain factors released by CAFs can modulate STAT3 signaling in other cell types in the tumor milieu. TGFβ, an evolutionarily conserved regulator of tumorigenesis, is a crucial driver of the activity of CAFs. Accumulating evidence suggests that TGFβ-stimulated CAFs increase the se...
2017. Targeted blockade of TGF-beta and IL-6/JAK2/STAT3 pathways inhibits lung cancer growth promoted by bone marrow-derived myofibroblasts. Sci Rep. 7:8660.J. Shi, J. Feng, J. Xie, Z. Mei, T. Shi, S. Wang, et al., Targeted blockade of TGF-β and IL-6/JAK2/STAT3 pathways ...
目的:研究泛Janus激酶(Janus kinase, JAK)抑制剂托法替布(tofacitinib)对转化生长因子-β1(transforming growth factor-beta 1, TGF-β1)诱导的肺成纤维细胞向肌成纤维细胞转化的作用及机制,为临床治疗结缔组织病相关的间质性肺疾病提供理论依据.方法:(1)体外培养人胚胎肺成纤维细胞(human fetal lung fibroblast ...
Woosley AN, Dalton AC, Hussey GS, Howley BV, Mohanty BK, Grelet S, Dincman T, Bloos S, Olsen SK, Howe PH. TGF beta promotes breast cancer stem cell self-renewal through an ILEI/LIFR signaling axis. Oncogene. 2019;38:3794–811. ...
信号通路-天然产物凋亡-结构类型-干细胞-信号通路Apoptosis-其他-STAT-TGF-beta/SmadAlantolactone 顶部相关产品生物活性化学信息储存和溶解信息TCMIP相关数据计算器参考文献文献引用为众多的药物研发团队赋能, 让新药发现更简单! Alantolactone 纯度: 99.91% 产品编号 T2896 别名土木香脑, 土木香内酯, Inula camphor, Hele...
Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-beta and integrin/focal adhesion kinase (FAK) signaling. Proc. Natl. Acad. Sci. USA 108, 10544–9 (2011). ADS CAS PubMed PubMed Central Google Scholar Kurebayashi, J. et al. Preferential antitumor effect ...