对于IL-10调节的抗炎作用,STAT3被认为是有助于炎症治疗和肠道稳态的关键效应分子。如图4,萝卜硫素进一步促进了LPS+IFN-γ处理诱导的BMDM中的STAT3活化。在中和αIL-10存在的情况下,萝卜硫素使pSTAT3/STAT3显著降低。此外,αIL-10中和显著上调了IL-1β和iNOS的基因表达水平,这些水平与LPS+IFN-γ处理的BMDM中的M1...
STAT3 is activated by multiple cytokines and growth factors including: IFN-a, IL-10, IL-6, IL-11, IL-12, IL-2, EGF etc. STAT3 functions as signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. In addition, STAT3...
not STAT1 was activated in response to ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), fibroblast growth factor-1 (FGF1), fibroblast growth factor-2 (FGF2), epidermal growth factor (EGF), interferon-alpha (IFN-alpha) and interferon-gamma (IFN-纬) in distinct patterns. ...
In cooperation with nuclear co-factors, phosphorylated STAT3 (pSTAT3) binds directly to gamma interferon activation site (GAS) elements in DNA promoter regions and activates gene expression [7], [8], [9]. In contrast to knock-out mice of other STAT family members, loss of STAT3 in mice ...
gamma, EGF, PDGF and IL6. Phosphorylation on tyrosine 705 by JAK1 and JAK2 is essential for STAT3 dimer formation, nuclear translocation, and DNA binding activity. In humans, the STAT3 gene is located on the q arm of chromosome 17. STAT3 has been shown to be activated by IFN-alpha but...
A role for STAT3 and cathepsin S in IL-10 down-regulation of IFN- g-induced MHC class II molecule on primary human blood macrophages. J Leukoc Biol 2010;88:303-11.Chan LL, Cheung BK, Li JC, Lau AS. A role for STAT3 and cathepsin S in IL-10 down-regulation of IFN-gamma- induced...
gamma, EGF, PDGF and IL6. Phosphorylation on tyrosine 705 by JAK1 and JAK2 is essential for STAT3 dimer formation, nuclear translocation, and DNA binding activity. In humans, the STAT3 gene is located on the q arm of chromosome 17. STAT3 has been shown to be activated by IFN-alpha but...
STAT3 can also be activated by Interferon-alpha, Interferon-gamma, EGF, PDGF and IL6. Phosphorylation on tyrosine 705 by JAK1 and JAK2 is essential for STAT3 dimer formation, nuclear translocation, and DNA binding activity. In humans, the STAT3 gene is located on the q arm of chromosome 17...
STAT3 can also be activated by Interferon-alpha, Interferon-gamma, EGF, PDGF and IL6. Phosphorylation on tyrosine 705 by JAK1 and JAK2 is essential for STAT3 dimer formation, nuclear translocation, and DNA binding activity. In humans, the STAT3 gene is located on the q arm of chromosome 17...
REG3gamma-deficient mice have altered mucus distribution and increased mucosal inflammatory responses to the microbiota and enteric pathogens in the ileum Mucosal Immunol., 7 (2014), pp. 939-947 View PDF Google Scholar F. Madouri, O. Barada, G. Kervoaze, F. Trottein, M. Pichavant, P. ...