Here, we confirmed that interferon-gamma (IFN-纬)-induced PD-L1 expression in melanoma cell lines. This increased expression was down-regulated by the reduction in phosphorylated STAT3 signaling via MET tyrosine kinase inhibitor treatment. Furthermore, immunoprecipitation and confocal ...
白细胞介素-12R 信号通过 STAT4 (p STAT4 表示 STAT4 活化磷酸化的形式) 进一步促进 TH1 扩张,导致了 γ-干扰素 (IFNgamma) 的表达。在的 TH1 环境适应性免疫反应控制肿瘤的生长。CD8 + T 细胞对肿瘤细胞的杀伤作用中有至关重要的作用。调节性 T (该细胞) 细胞是重要的负调节 TH1 抗肿瘤免疫。STAT5 ...
A role for STAT3 and cathepsin S in IL-10 down-regulation of IFN-gamma-induced MHC class II mole- cule on primary human blood macrophages. J Leukoc Biol;88:303-11.Lally L.Y Chan,Benny K.W.Cheung,James C.B.Li,Allan S.Y.Lau.A role for STAT3 and cathepsin S in IL-10 down-...