Stat3-mediated Tumor Escape T Follicular Helper Cell Pathway TH1 Pathway (Cellular Immune Response) Th17 Biology TH2 Pathway (Humoral Immune Response) Pages Quality Control ELISA Kits and Sets Related FAQs There are no FAQs for this product. Certificate of Analysis Lot #: Customers...
Platinum(IV) Complexes as Inhibitors of STAT3 and Regulators of the Tumor Microenvironment To Control Breast Cancer Authors - Linxiang Cai View Article mouse FC (Intra) Hum Cell Tetramerization of pyruvate kinase M2 attenuates graft-versus-host disease by inhibition of Th1 and Th17 differentiation Au...
A role for STAT3 and cathepsin S in IL-10 down-regulation of IFN-gamma-induced MHC class II molecule on primary human blood macrophages. J Leukoc Biol. 2010; 88 :303–311. doi: 10.1189/jlb.1009659. [ Cross Ref ]Chan LLY, Cheung BKW, Li JCB, Lau ASY: A role for STAT3 and ...
IFNGR1 还促进 STAT3 的激活,尽管程度较小。此外,磷酸化的 IFNGR1 结构域为 SOCS1 提供了一个对接位点,SOCS1 通过与 STAT1 竞争与 IFNGR1 的结合来调节 JAK-STAT 通路。IFNGR1可以单体存在,并与IFNGR2形成异二聚体,构成IFNG受体复合物。该受体还与 JAK1、STAT1 和 SOCS1 相互作用,协调复杂的信号网络以响应 ...
theunbalancedcompetitionbetweenSTAT1andSTAT3forIFNRandgp130ledtopreferentialactivationofIFN-gammaandIL-6,whileatthesametimetheformationofSTAT1/3heterodimersenhancedpreferentialsignaltransductionbysequesteringafractionoftheactivatedSTATs.Themodelprovidedagoodexplanationoftheexperimentalobservationsandprovidedinsightsthatmayinform...
Results Using established mathematical models and new experimental observations of the crosstalk between the IFN-gamma and IL-6 pathways, we constructed a new crosstalk model that considers three possible crossta...
Stat3-mediated Tumor Escape T Follicular Helper Cell Pathway TH1 Pathway (Cellular Immune Response) Th17 Biology TH2 Pathway (Humoral Immune Response) Pages Quality Control Multicolor Staining Guide Fluorescence Spectra Analyzer Fluorophore Brightness Index Interleukin Receptors Chemokines and ...
Important transcription factors for the transcription and secretion of IL-17 from Th17 cells are RORγt and STAT3. IL-17 itself induces production of effector molecules in IL17R expressing cells like endothelial cells, epithelial cells or fibroblasts, macrophages and dendritic cells, chondrocytes and ...
Here, we confirmed that interferon-gamma (IFN-纬)-induced PD-L1 expression in melanoma cell lines. This increased expression was down-regulated by the reduction in phosphorylated STAT3 signaling via MET tyrosine kinase inhibitor treatment. Furthermore, immunoprecipitation and confocal ...
SOCS1 and SOCS3 overexpression in keratinocyte stable clones inhibited IFN-gamma-induced phosphorylation of IFN-gammaRalpha and activation of STAT1 and STAT3. Furthermore, SOCS1 and, to a lesser extent, SOCS3 reduced membrane expression of ICAM-1 and HLA-DR, and release of IFN-gamma-inducible ...