We found that enhanced IFN/STAT signaling in CFAP conferred resistance to MEK inhibitors. These findings reveal the crosstalk between RAS signaling and IFN/STAT signaling, which contributes to the tumor‐forming potential and drug response. These results offer a rationale for targeting of IFN/STAT ...
W1176 Heme Oxygenase-1 Suppresses IL-12 Secretion with Inhibition of IFN-Stat Signaling: A Potential Therapeutic Target for TH1-Type ColitisW1176 Heme Oxygenase-1 Suppresses IL-12 Secretion with Inhibition of IFN-Stat Signaling: A Potential Therapeutic Target for TH1-Type Colitis0454 Isotopic composi...
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IFN-τ主要通过JAK-STAT信号转导途径发挥多效生物学功能。本文介绍了IFN-τ介导的信号转导途径JAK-STAT中的主要功能元件JAKs和STAT的结构和功能,并重点阐述了该信号转导途径的具体传递过程和调节方式。关键词:IFN-τ;信号传递;JAK-STAT中图分类号:Q25收稿日期:2008-12-02山东省科技厅项目(No.0310501010)资助作者...
B. (2002) Sensitization of IFN-gamma Jak- STAT signaling during macrophage activation. Nat. Immunol. 3, 859-65.Hu X, Herrero C, Li WP, Antoniv TT, Falck-Pedersen E, Koch AE, Woods JM, Haines GK III, Ivashkiv LB: Sensitization of IFN- gamma Jak-STAT signaling during macrophage ...
Available online 17 September 2024, 110249 In Press, Journal Pre-proofWhat’s this?GRP78 exerts antiviral function against influenza A virus infection by activating the IFN/JAK-STAT signaling Author links open overlay panelJiaxin Liu a 1, Kanghong Chen b 1, Wenjiao Wu a, Zefen Pang c, ...
(2000). IFN-beta induces serine phosphorylation of Stat-1 in Ewing’s sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7. Oncogene 19 , 3372–3383.Sanceau J, Hiscott J, Delattre O, Wietzerbin J. (2000). IFN- beta induces serine phosphorylation of ...
IFN-λR1STAT5A目的 研究RanBPM调控IFN-λR1-STAT信号通路的分子机制.方法 利用免疫共沉淀和双荧光素酶报告基因等方法检测IFN-λR1中与STAT5A结合的位点,RanBPM与STAT5A的相互作用和相互作用的结构域,以及相互作用后对STAT5A报告基因活性的影响.结果 IFN-λR1中含有两个与STAT5A结合的位点;STAT5A能与RanBPM相互...
阻止细胞快速生长以及调节细胞分化过程中发挥着重要的作用.INFR由INFARI和IN-FAR2组成,而IFNAR1在信号转导中发挥重要的作用.信号转导分子与转录激活物(signal tranduc-ers and activators of transcription,STAT)是一种急性时相反应基因的转录因子.其酪氨酸磷酸化后,可以组装成同源或异源二聚体,选择性激活IFN激活...
et al.β-sitosterol ameliorates influenza A virus-induced proinflammatory response and acute lung injury in mice by disrupting the cross-talk between RIG-I and IFN/STAT signaling. Acta Pharmacol Sin 41, 1178–1196 (2020). https://doi.org/10.1038/s41401-020-0403-9 Download citation Received20...