Platinum(IV) Complexes as Inhibitors of STAT3 and Regulators of the Tumor Microenvironment To Control Breast Cancer Authors - Linxiang Cai View Article mouse FC (Intra) Hum Cell Tetramerization of pyruvate kinase M2 attenuates graft-versus-host disease by inhibition of Th1 and Th17 differentiation Au...
Here, we confirmed that interferon-gamma (IFN-纬)-induced PD-L1 expression in melanoma cell lines. This increased expression was down-regulated by the reduction in phosphorylated STAT3 signaling via MET tyrosine kinase inhibitor treatment. Furthermore, immunoprecipitation and confocal ...
Stat3-mediated Tumor Escape T Follicular Helper Cell Pathway TH1 Pathway (Cellular Immune Response) Th17 Biology TH2 Pathway (Humoral Immune Response) Pages Quality Control ELISA Kits and Sets Related FAQs There are no FAQs for this product. Certificate of Analysis Lot #: Customers...
IFNGR1 还促进 STAT3 的激活,尽管程度较小。此外,磷酸化的 IFNGR1 结构域为 SOCS1 提供了一个对接位点,SOCS1 通过与 STAT1 竞争与 IFNGR1 的结合来调节 JAK-STAT 通路。IFNGR1可以单体存在,并与IFNGR2形成异二聚体,构成IFNG受体复合物。该受体还与 JAK1、STAT1 和 SOCS1 相互作用,协调复杂的信号网络以响应 ...
Stat3-mediated Tumor Escape T Follicular Helper Cell Pathway TH1 Pathway (Cellular Immune Response) Th17 Biology TH2 Pathway (Humoral Immune Response) Pages Quality Control Multicolor Staining Guide Fluorescence Spectra Analyzer Fluorophore Brightness Index ...
Results Using established mathematical models and new experimental observations of the crosstalk between the IFN-gamma and IL-6 pathways, we constructed a new crosstalk model that considers three possible crosstalk levels: (1) the competition between STAT1 and STAT3 for common receptor docking sites; ...
STAT1andSTAT3forcommonreceptordockingsites;(2)themutualnegativeregulationbetweenSOCS1andSOCS3;and(3)thenegativeregulatoryeffectsoftheformationofSTAT1/3heterodimers.Anumberofsimulationsweretestedtoexploretheconsequencesofcross-regulationbetweenthetwopathways.Thesimulationresultsagreedwellwiththeexperimentaldata,thereby...
在的 TH1 环境适应性免疫反应控制肿瘤的生长。CD8 + T 细胞对肿瘤细胞的杀伤作用中有至关重要的作用。调节性 T (该细胞) 细胞是重要的负调节 TH1 抗肿瘤免疫。STAT5 是该细胞细胞分化和扩大的关键。STAT5 和 STAT3 促进表达的叉头框 P3,t 细胞的标记...
A role for STAT3 and cathepsin S in IL-10 down-regulation of IFN-gamma-induced MHC class II mole- cule on primary human blood macrophages. J Leukoc Biol;88:303-11.Lally L.Y Chan,Benny K.W.Cheung,James C.B.Li,Allan S.Y.Lau.A role for STAT3 and cathepsin S in IL-10 down-...
Although we could confirm the enhanced induction of PY-STAT1 by IFN-beta after IFN-gamma priming of primary human monocytes, the formation of PY-STAT3 remained the same. In contrast, we observed strongly increased IFN-beta-induced activation of STAT5 after pre-exposure of primary human monocytes...