2000. TGF-beta1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA- 3 expression. Eur. J. Immunol. 30:2639.Heath VL, Murphy EE, Crain C et al (2000) TGF-beta1 down-regulates Th2 development and results in decreased IL-4-induced STAT...
[154,155]or its triggering induces TGF-β, which in turn acts profibrotically[156,157]. Activation of the IL-4R complexes initiates complex intracellular signaling utilizing members of the JAK family of tyrosine kinases, the IRS family of proteins, STAT6, and other intracellular signaling ...
研究表明,TGF-beta/Smad具有抑癌和促癌的双重作用。它可以抑制细胞的生长和增殖,可诱导癌前细胞凋亡,抑制癌细胞增殖,所以TGF-beta/Smad被认为是开发癌症治疗药物的重要靶点之一。 百灵威提供TGF-beta/Smad抑制剂等活性小分子: 靶点清晰明确,便于选择; 严格的质检,确保产品高纯度、高品...
机译:JAK2 / Y343 / STAT 5信号轴是促红细胞生成素介导的抗肾小管上皮细胞缺血性损伤的保护所必需的。 Breggia, Anne C. 2008 6.Hepatitis B virus X protein modulates apoptosis in human renal proximal tubular epithelial cells by activating the JAK2/STAT3 signaling pathway and spring 机译:乙型肝...
SB-505124抑制紧密相关的ALK4,IC50为129 nM,选择性比作用于ALK5低2.5倍。SB-505124浓度高达10 μM时也不抑制ALK2。SB-505124抑制COS-1细胞内源性Smad2磷酸化。ALK4和ALK5激活Smad1和Smad2,加入SB-505124抑制激活。SB-505124作用于HepG2人类肝癌细胞,C2C12小鼠成肌细胞和Mv1Lu水貂肺细胞,浓度依赖性抑制转化生长...
Recently, Myostat... X Cheng,W Gang,Y Zohar,... - 《Journal of Experimental Biology》 被引量: 484发表: 2003年 Left-right asymmetric expression of the TGFbeta-family member lefty in mouse embryos. Describes a member of the transforming growth factor-beta family called the lefty gene which...
Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila (2006). TGF beta: the molecular Jekyll and Hyde of cancer. Nat. Rev. Cancer 6, 506-520.Genome-wide RNAi analysis of JAK/STAT signaling components ... Baeg,G.-H. - 《Genes & Development》 被引量: 406发表: 2005...
Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival. During viral infection, effector CD8 T cells contract to form a population of protective memory cells that is maintained by 1L-7 and lL-15. The mechanisms ... Hand,Timothy,W.,... - 《Proceed...
Suitable collagen materials include Collastat™ and Helistat™ collagen sponges (Integra LifeSciences Corp., Plainsboro, N.J.). Other collagen materials which may be suitable for use in the present invention are described in U.S. Pat. No. 5,206,028; U.S. Pat. No. 5,024,841; U.S...
We found that IL-6 induced c-Maf expression in CD4(+) T cells and that the enforced expression of c-Maf induced IL-21 production in CD4(+) T cells without IL-6, IL-4/STAT6 signaling, or an autocrine effect of IL-21. Moreover, we found that c-Maf directly bound to and ...