[26] Xu, P., et al. (2012). Post-translational regulation of TGF-betareceptor and Smad signaling. FEBS Lett 586, 1871-84.
[26] Xu, P., et al. (2012). Post-translational regulation of TGF-betareceptor and Smad signaling. FEBS Lett 586, 1871-84.
TGF-β&PD-L1：全球及中国临床在研药物浅析（下）导言 转化生长因子-β（Transforming growth factor-beta，TGF-β）是一种多功能细胞因子，属于转化生长因子超家族。近年来，越来越多的研究认为TGF-β是一种关键的免疫抑制剂，可以减少肿瘤浸润和过继免疫细胞转移疗法的疗效，特别是对于实体瘤。然而，受全球TGF-β...
转化生长因子-β（Transforming growth factor-beta，TGF-β）是一种相对分子质量为25-kDa的二聚体蛋白，由两个亚基组成，是一种多功能细胞因子，属于转化生长因子超家族。转化生长因子超家族包括骨形态发生蛋白（BMPs）、生长分化因子（GDFs）、胶质源性神经营养因子（GDNFs）、激活素、抑制素等各种各样的蛋白质家族...
TGF-β 信号通路促癌还是抑癌 - MCE 转化生长因子 (Transforming growth factor beta，TGF-β) 是一类多功能的细胞因子，可由多种组织细胞产生。TGF-β 信号通路是由众多成员的多功能细胞因子，与相应的受体、细胞内信号转导分子组成的通路，能影响疾病发生和发展，调节基因的转录，控制着细胞周期，影响细胞的增殖...
1.Massagué J. TGFbeta in Cancer.Cell. 2008 Jul 25;134(2):215-30. doi: 10.1016/j.cell.2008.07.001. PMID:18662538; PMCID: PMC3512574. 2.Vander Ark A, et al. TGF-βreceptors: In and beyond TGF-β signaling. Cell Signal. 2018 Dec;52:112-120.doi: 10.1016/j.cellsig.2018.09.002...
[11] Wrighton,K. H., et al. (2009). Phospho-control of TGF-beta superfamily signaling. CellRes 19, 8-20. [12] Conery,A. R., et al. (2004). Akt interacts directly with Smad3 to regulate thesensitivity to TGF-beta induced apoptosis. Nat Cell Biol 6, 366-72. ...
[1] Feng,X. H. , et al. (2005). Specificity and versatility in tgf-beta signalingthrough Smads. Annu Rev Cell Dev Biol 21, 659-93. [2] Heldin,C. H., et al. (1997). TGF-beta signalling from cell membrane to nucleus throughSMAD proteins. Nature 390, 465-71. ...
TGFbeta in Cancer. Cell. 2008;134(2):215-230.12. Gryfe R, Kim H, Hsieh ET, et al. Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer. N Engl J Med. 2000; 342(2):69-77.13. Papageorgis P, Stylianopoulos T. Role of TGFβ in regulation...