应用AG490治疗后,TGF-β1的表达下降,说明JAK-STAT信号通路的特异性抑制剂AG490可以抑制JAK信号通路的激活,拮抗TGF-β1的表达,从而阻止肾组织的进一步损伤。 综上所述,AG490可能通过TGF-β1来阻断JAK/STAT3信号通路的激活,进而抑制创伤性休克肾损伤的发展,JAK/STAT3信号通路的激活有可能成为治疗创伤性休克肾损伤的一个...
In the current study, we demonstrated that upregulated TGF-beta may promote epithelial-mesenchymal transition (EMT) through STAT3 activation. In addition, we explored the contributions of STAT3 to HNSCC with a specific focus on its transcriptional regulation and its interaction with the long non...
TGF-beta has paradoxical and context dependent effects on proliferation and anoikis in human colorectal cancer cell lines. Transforming growth factor-beta (TGF-beta) is a pluripotent cytokine that can have both tumor suppressing and tumor promoting effects on epithelial cells. ... NM Muñoz,YB Ji...
In this review, we discuss the upstream activators of STAT3 in skeletal muscles, with a focus on interleukin 6 (IL6) and transforming growth factor beta 1 (TGF-β1). We will also discuss the double-edged effect of STAT3 activation in the muscles, including the role of STAT3 signaling in...
The transforming growth factor beta (TGF-beta) superfamily signals to the Smad pathway through heteromeric Ser-Thr kinase receptors that are r... GMD Guglielmo,CL Roy,AF Goodfellow,... - 《Nature Cell Biology》 被引量: 1317发表: 2003年 Implications of an antiparallel dimeric structure of non...
TGF-beta down-regulates IL-6 signaling in intestinal epithelial cells: critical role of SMAD-2. Interleukin-6 (IL-6) is a pro-inflammatory cytokine that plays an important role in the pathogenesis of inflammatory bowel disease. TGF-beta, a multifuncti... B Walia,L Wang,D Merlin,... - ...
Transforming growth factor beta (TGF-beta) and inflammation in cancer Cytokine Growth Factor Rev., 21 (2010), pp. 49-59 View PDFView articleView in ScopusGoogle Scholar Chen and O'Shea, 2008 Z. Chen, J.J. O'Shea Th17 cells: a new fate for differentiating helper T cells Immunol. Res...
结果:单细胞测序数据发现IPF患者肺成纤维细胞PMEPA1水平显著高于供体肺成纤维细胞,在IPF患者肺组织及BLM气道滴注的小鼠肺组织中,PMEPA1的表达水平也显著升高;在成纤维细胞体外培养中,转化生长因子β1(transforming growth factor-beta 1,TGF-β1)可促进 PMEPA1 的表达,敲除 PMEPA1表达可抑制成纤维细胞分化,增殖,...
STAT3 integrates cooperative Ras and TGF-beta signals that induce Snail expression. Oncogene 2016, 35, 1049-1057. [CrossRef] [PubMed]Saitoh M, Endo K, Furuya S, Minami M, Fukasawa A, Imamura T and Miyazawa K. STAT3 integrates cooperative Ras and TGF-beta signals that induce Snail ...
[2] Lin L, et al. The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling. Oncogene 28(7): 961-972(2009). [3] Pang M, et al. A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in ...