Interestingly, ELF, a beta-spectrin and a downstream adaptor protein of TGF-beta signaling, modulates STAT3 function. Overexpression of ELF inhibits the transcriptional activity of STAT3 by two folds as compared to control vector in hepatocellular carcinoma cell line. We conclude thatTGF-beta pathway...
However, the underlying mechanisms of STAT3 overexpression and regulation of HNSCC metastasis remain unknown. In the current study, we demonstrated that upregulated TGF-beta may promote epithelial-mesenchymal transition (EMT) through STAT3 activation. In addition, we explored the contributions of STAT3 ...
TGF-beta 1 could induce EMT along with an E-cadherin decrease, while vimentin, Snail, p-Smad2/3, and p-STAT3/STAT3 increase in HepG2. SIS3 (a specific inhibitor of Smad3) could markedly inhibit Snail, Vim and p-STAT3 along with blocking phosphorylation of Smad3, but E-cadherin could...
Furthermore, STAT3 overexpression partly counteracted the miR-20a-5p-induced anti-apoptotic effect in TGF-beta 1-treated BEAS-2B cells. In summary, this study suggested that miR-20a-5p restrained apoptosis in TGF-beta 1-stimulated BEAS-2B cells by targeting STAT3. MiR-20a-5p thus may be a...
Downregulation of IL-6-induced STAT3 tyrosine phosphorylation by TGF-beta1 is mediated by caspase-dependent and -independent processes. Leukemia 16, 675-682 (2002).Wierenga, A.T., et al., Downregulation of IL-6-induced STAT3 tyrosine phosphorylation by TGF-beta1 is mediated by caspase-...
BACKGROUND: Our recent work showed that in patients with Montreal B2 Crohn's disease TGF-[beta]1 anddoi:10.1097/01.MIB.0000439004.84811.b3Li, ChaoKuemmerle, JayInflammatory Bowel Diseases
183 POSTER TGF-beta-induced Stat3 phosphorylation mediated growth regulation in lung cancerABSTRACTdoi:10.13140/RG.2.1.4565.7127Basanta Raj AdhikariMadan Krishna SuwalELSEVIEREuropean Journal of Cancer Supplements
TGF-β1 suppresses IL-6-induced STAT3 activation through regulation of Jak2 expression in prostate epithelial cells[J] . Cellular Signalling . 2010 (11)Starsichova A, Lincova E, Pernicova Z, et al: TGF‑beta1 suppresses IL‑6‑induced STAT3 activation through regulation of Jak2 ...
EphrinB2 Regulates Cardiac Fibrosis Through Modulating the Interaction of Stat3 and TGF-beta/Smad3 Signaling. Circ Res. (2017) 121:617-27. doi: 10.1161/CIRCRESAHA.117.311045Su SA, Yang D, Wu Y, Xie Y, Zhu W, Cai Z, et al. EphrinB2 reg- ulates cardiac fibrosis through modulating the...
LncRNA AFAP1&8208AS1miR&8208424&82085pSTAT3Aim Endometriosis is a common gynecological disorder characterized by chronic pelvic pain and infertility, which negatively affects women's health worldwide. AFAP1-AS1 has been implicated in endometriosis lesions recently, but its mechanism of endometriosis ...