In the current study, we demonstrated that upregulated TGF-beta may promote epithelial-mesenchymal transition (EMT) through STAT3 activation. In addition, we explored the contributions of STAT3 to HNSCC with a specific focus on its transcriptional regulation and its interaction with the long non...
应用AG490治疗后,TGF-β1的表达下降,说明JAK-STAT信号通路的特异性抑制剂AG490可以抑制JAK信号通路的激活,拮抗TGF-β1的表达,从而阻止肾组织的进一步损伤。 综上所述,AG490可能通过TGF-β1来阻断JAK/STAT3信号通路的激活,进而抑制创伤性休克肾损伤的发展,JAK/STAT3信号通路的激活有可能成为治疗创伤性休克肾损伤的一个...
Transforming growth factor-beta (TGF-beta) is a pluripotent cytokine that can have both tumor suppressing and tumor promoting effects on epithelial cells. ... NM Muñoz,YB Ji,WM Grady - 《Growth Factors》 被引量: 39发表: 2008年 Cytochrome P-450 2C9 exerts a vasoconstrictor influence on ...
STAT3 integrates cooperative Ras and TGF-beta signals that induce Snail expression. Oncogene 2016, 35, 1049-1057. [CrossRef] [PubMed]Saitoh M, Endo K, Furuya S, Minami M, Fukasawa A, Imamura T and Miyazawa K. STAT3 integrates cooperative Ras and TGF-beta signals that induce Snail ...
In this review, we discuss the upstream activators of STAT3 in skeletal muscles, with a focus on interleukin 6 (IL6) and transforming growth factor beta 1 (TGF-β1). We will also discuss the double-edged effect of STAT3 activation in the muscles, including the role of STAT3 signaling in...
The transforming growth factor beta (TGF-beta) superfamily signals to the Smad pathway through heteromeric Ser-Thr kinase receptors that are r... GMD Guglielmo,CL Roy,AF Goodfellow,... - 《Nature Cell Biology》 被引量: 1317发表: 2003年 Implications of an antiparallel dimeric structure of non...
TGF-beta down-regulates IL-6 signaling in intestinal epithelial cells: critical role of SMAD-2. Interleukin-6 (IL-6) is a pro-inflammatory cytokine that plays an important role in the pathogenesis of inflammatory bowel disease. TGF-beta, a multifuncti... B Walia,L Wang,D Merlin,... - ...
IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells Nat. Immunol., 9 (2008), pp. 1347-1355 CrossrefView in ScopusGoogle Scholar Das et al., 2009 J. Das, G. Ren, L. Zhang, A.I. Roberts, X. Zhao,...
7. =Wang, H. et al. TGF-beta1-induced epithelial-mesenchymal transition in lung cancer cells involves upregulation of miR-9 and downregulation of its target, E-cadherin. Cell Mol. Biol. Lett. 22, 22 (2017). 8....
结果:单细胞测序数据发现IPF患者肺成纤维细胞PMEPA1水平显著高于供体肺成纤维细胞,在IPF患者肺组织及BLM气道滴注的小鼠肺组织中,PMEPA1的表达水平也显著升高;在成纤维细胞体外培养中,转化生长因子β1(transforming growth factor-beta 1,TGF-β1)可促进 PMEPA1 的表达,敲除 PMEPA1表达可抑制成纤维细胞分化,增殖,...