Small molecule inhibitors of CXCR4. Theranostics 3, 47–75 (2013). CAS PubMed PubMed Central Google Scholar Yan, M. et al. Recruitment of regulatory T cells is correlated with hypoxia-induced CXCR4 expression, and is associated with poor prognosis in basal-like breast cancers. Breast ...
Small molecule and peptide CXCR4 antagonists. A patent review from 2019 to 2024 View further author informationDennis C. LiottaView further author informationljwilso@emory.edu wilsonlarr@gmail.comLawrence J. WilsonView further author informationJiafeng GengView further author informationYesim A. Tahi...
Kazmierski W, Gudmundsson KS, and Piscitelli SC (2007) Small molecule CCR5 and CXCR4-based viral entry inhibitors for anti-HIV therapy currently in develop- ment. Annu Rep Med Chem 42:301-320.Chapter 19 Small Molecule CCR5 and CXCR4-Based Viral Entry Inhibitors for Anti-HIV...
These small-molecule inhibitors interrupt certain protein pathways, and this can lead to decreased cancer cell development and proliferation [45]. In pancreatic cancer, small-molecule inhibitor (SMI) drugs inhibit pathways including HSP90, FAK, Hedgehog signaling, Bcl-2, Mcl-1, KRAS signaling, and...
(2010). Structures of the CXCR4 chemo- kine GPCR with small-molecule and cyclic peptide antagonists. Science 330, 1066-1071.Wright, S. I., and B... S.,I.,Wright - 《Genetics》 被引量: 446发表: 2004年 Germ Cell Genes and Cancer (2010). Structures of the CXCR4 chemokine GPCR with...
CXCR4 and its ligand SDF1α (stromal derived factor-1α or CXCL12) play an important role in cancer metastasis, regulation of stem cell trafficking and neovascularization. We have observed previously that treatment with the small molecule CXCR4 antagonists Plerixafor (AMD3100, Mozobil) and AMD3465...
HIV entry into the cell involves the presence of at least two chemokine coreceptors, the CCR5 and CXCR4 receptors. Much research by the major drug companies has ultimately been directed to the development of small molecule chemokine antagonists that inhibit virus entry into the cell and in this...
Lung cancer represents the leading cause of cancer-related mortality throughout the world. Patients die of local progression, disseminated disease, or both. At least one third of the people with lung cancer develop brain metastases at some point during t
PAK4—a member of the PAK family of serine threonine kinases, linked with PI3K/AKT and Wnt/β-catenin signaling—has been identified as a promising therapeutic target in cancer [211,212]. With two small molecule inhibitors of PAK4 currently being evaluated in Phase I basket trials in solid ...
RECENT FINDINGS: Entry of HIV-1 into t... Kuritzkes,R Daniel - 《Current Opinion in Hiv & Aids》 被引量: 223发表: 2009年 Development of peptide and small-molecule HIV-1 fusion inhibitors that target gp41. It has been 25 years since the development of the first efficient HIV-1/AIDS ...