1163), PKR inhibitor (C 13 H 8 N 4 OS, imoxin), and a neg- ative control of PKR inhibitor (C 15 H 8 Cl 3 NO 2 ) were purchased from Calbiochem (Gibbstown, NJ). Anti- phospho-JNK (Thr183/Tyr185) antibody was purchased
g, Durability analysis in KIF18A-inhibitor-sensitive cancer cell lines (n = 5); cells were treated for 6 d with DMSO or AM-0277 (0.5 µM). MCF-7 cells were treated with palbociclib (1 µM) as a cytostatic control. After the treatment phase (left), cells were re...
(2003) The selective tyrosine kinase inhibitor, STI571, inhibits growth of anaplastic thyroid cancer cells. J Clin Endocrinol Metab 88: 1889–1896 Article CAS Google Scholar Dziba JM and Ain KB (2004) Imatinib mesylate (Gleevec; STI571) monotherapy is ineffective in suppressing human anaplastic...
Small molecule inhibitors for target or IRE1 protein family members are provided herein. The bond may be direct or indirect. In addition, the use of the IRE1 small molecule inhibitor used to treat or improve the targeted cancer is provided herein. Furthermore, the IRE1 small molecule ...
MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps. 来自 NCBI 喜欢 0 阅读量: 144 作者: S Kasibhatla,V Baichwal,SX Cai,B Roth,I Skvortsova,S Skvortsov,P Lukas,NM English,N Sirisoma,J Drewe 展开 ...
An inhibitor of P-glycoprotein resistance protein-1, namely MS-209, was also referred as a SMS inhibitor, but there was no further specific experimental data to support this view [10], [11], [12]. We have synthesized MS-209, and the result of its SMS inhibitory activity assay (D609 ...
However, a caspase inhibitor did not inhibit this caspase-dependent cell death. NCO-01/04 enhanced the endonuclease G level in the nucleus with loss of the mitochondrial transmembrane potential, which can promote caspase-independent death. Interestingly, NCO-01/04 increased the LC3-II-enriched ...
et al. A small-molecule inhibitor of BamA impervious to efflux and the outer membrane permeability barrier. Proc. Natl Acad. Sci. USA 116, 21748–21757 (2019). Article CAS PubMed PubMed Central Google Scholar Mateus, A. et al. Thermal proteome profiling in bacteria: probing protein state...
One compound, 14 (1,2,4,5-benzenetetraamine tetrahydrochloride), significantly decreased viability in most of the cells to the levels equal to or higher than control FAK inhibitor 1a (2-[5-chloro-2-[2-methoxy-4-(4-morpholinyl)phenylamino]pyrimidin-4-ylamino]-N-methylbenzamide, TAE226) from...
potential small-molecule inhibitors were developed by virtual screening based on the crystal structure of the NEMO/IKKβ complex. However, no potent small-molecule inhibitor has been reported to effectively disrupt the NEMO/IKKβ complex in vivo, although some small-molecule inhibitors with modest pot...