The chemotactic migration of neutrophils in response to SDF-1 was reduced after a pre-incubation with lithium. We provide evidence that lithium down-regulates the CXCR4 expression of neutrophils and it attenuates their responsiveness to SDF-1. Our studies support the concept that down-regulation of...
neutrophils in mice exposed to a pro-allergic low dose of lipopolysaccharide (LPS) or a protective high dose of LPS before exposure to house dust mites. Unlike exposure to a high dose of LPS, exposure to a low dose of LPS instructed recruited neutrophils to upregulate their expression of the...
infiltration of infected lymphocytes in tumor was presented (Hengge et al., 2002). However, the final infectability of cells by HIV via CXCR7 will depend on its overall surface expression. HIV potentially using CXCR7 as a co-entry receptor must be considered in all the strategies to develop...
cxcr4bis highly expressed in neutrophils and loss of function results in reduced triple negative breast cancer burden. (A)cxcr4aandcxcr4bexpression levels were quantified in neutrophils and compared to the GFP negative cell population. Data are read counts from RNA sequencing performed on three bio...
Fang et al. showed increased CXCR4 expression in esophageal malignancies, with most of the signal coming from immune cells (neutrophils and T cells), and not esophageal fibroblasts or endothelial cells [14]. This finding adds to earlier observations, describing that neutrophils contributed to carcino...
Cutting Edge: IL-4 Induces Functional Cell-Surface Expression of CXCR4 on Human T Cells1 Cutting edge: IL-4 induces functional cell-surface expression of CXCR4 on human T cells. J. Immunol. 160:4153.Jourdan, P., Abbal, C., Nora, N... P Jourdan,C Abbal,N Nora,... - 《Journal...
产品介绍 Catalogue Number :16912-60 Description The 2B11 monoclonal antibody specifically reacts with mouse CD184 (CXCR4or Fusin), a seven-transmembrane G-protein-coupled receptor. It is expressed by astrocytes, B cells, T cells, monocytes, neutrophils, neurons, and hematopoietic cell types. CD...
expression was quantified using immunohistochemistry or an equivalent technique, and the experiments were duplicated. The data are presented as Mean ± Standard Deviation (SD), emphasizing sample variability. This analysis elucidates the effects of AMD3100 and A1 on the expression of ...
The chemokine receptorCXCR4belongs to G-protein coupled receptors (GPCRs) and is broadly expressed on most hematopoietic cell types includingneutrophils,monocytesand macrophages, immature and mature T and B-lymphocytes, hematopoietic and endothelial progenitor stem cells,vascular endothelial cells, neurons,...
Forster, R. et al. Intracellular and surface expression of the HIV-1 coreceptor CXCR4/fusin on various leukocyte subsets: rapid internalization and recycling upon activation.J. Immunol.160, 1522–1531 (1998). CASPubMedGoogle Scholar Casamayor-Palleja, M., Mondiere, P., Verschelde, C., Bel...