Recent advances in single-cell sequencing technology concerning genomics and epigenomics open new avenues to dissect cell heterogeneity in multiple biological processes. Recent applications of these approaches to plants have provided exciting insights into diverse biological questions. We highlight the ...
CHAPTER 9 Single-Cell Genomics: Technology and Applications CHAPTER 10 Single-Cell Metagenomics CHAPTER 11 Single-Cell Epigenomics: Technology and Applications CHAPTER 12 Single-Cell Transcriptomics: Technology and Applications CHAPTER 13 Single-Cell Transcriptomics and Proteomics of Skeletal Muscle: Technology...
For example, single-cell genomics will help to uncover cell lineage relationships; single-cell transcriptomics will supplant the coarse notion of marker-based cell types; and single-cell epigenomics and proteomics will allow the functional states of individual cells to be analysed. These technologies ...
S. et al. Supporting data for “Dissecting the cellular architecture of neuroblastoma bone marrow metastasis using single-cell transcriptomics and epigenomics unravels the role of monocytes at the metastatic niche” (1.0.0). Zenodo, https://doi.org/10.5281/zenodo.7707614 (2023). Fetahu, I. S....
& Reik, W. Single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity. Genome Biol. 17, 72 (2016). Article PubMed PubMed Central CAS Google Scholar Marinov, G. K. et al. From single-cell to cell-pool transcriptomes: stochasticity in gene expression ...
Single-cell epigenomics: Recording the past and predicting the future Gavin Kelsey, Oliver Stegle, Wolf Reik Abstract Single-cell multi-omics has recently emerged as a powerful technology by which different layers of genomic output—and hence cell identity and function—can be recorded simultaneously....
Here, we review single-cell sequencing techniques for individual and multiomics profiling in single cells. We mainly describe single-cell genomic, epigenomic, and transcriptomic methods, and examples of their applications. For the integration of multilay
D. Single-cell and single-molecule epigenomics to uncover genome regulation at unprecedented resolution. Nat. Genet. 51, 19–25 (2019). CAS PubMed Google Scholar Ludwig, C. H. & Bintu, L. Mapping chromatin modifications at the single cell level. Development 146, dev170217 (2019). CAS ...
These studies demonstrate how the integration of single-cell epigenomics sequencing with other single-cell omics methods offers valuable insights into the epigenomic characteristics of various types of leukemia, facilitating a deeper understanding of the disease. ...
(SNPs) with epigenomics, transcriptomics, 3D chromatin organization from diverse cell types as well as primary UF patient’s samples. This integrative analysis identifies 24 UF-associated risk loci that potentially target 394 genes, of which 168 are differentially expressed in UF tumors. Critically, ...