The Epigenomics of Cancer 来自 Semantic Scholar 喜欢 0 阅读量: 212 作者: I Hatada 摘要: Epigenomics is the genome-wide study of epigenetics such as DNA methylation and histone modification. Epigenetic abnormality plays an important role in the pathogenesis of most cancers. Among these mo DOI...
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The epigenomics of cancer. Aberrant gene function and altered patterns of gene expression are key features of cancer. Growing evidence shows that acquired epigenetic abnormalities pa... PA Jones,SB Baylin - 《Cell》 被引量: 7225发表: 2007年 Lung cancer epigenetics and genetics Lung cancer is ...
Cancer testis antigens (CTAs). A group of proteins expressed during male germ cell development, which are silenced in normal cells and may become re-expressed ectopically in cancers. Many are highly immunogenic. Monotherapies The use of a single drug to treat a malignancy. ...
EpigenomicsThe article focuses on the cancer epigenome. It discusses chromatin, DNA methylation, and nucleosome occupancy and methylation sequencing. It mentions DNA methylation as a key aspect for cancer, transcriptional mutations in cancer, and DNA repair enzymes mutations. It also mentions that ...
Epigenetic diet: impact on the epigenome and cancer A number of bioactive dietary components are of particular interest in the field of epigenetics. Many of these compounds display anticancer properties and ... TM Hardy,TO Tollefsbol - 《Epigenomics》 被引量: 267发表: 2011年 ...
Genetic mechanisms of mutation, copy number alteration, insertion, deletion, and recombination are particularly well suited as vehicles of persistent phenotypic change. For this reason, cancer has long been viewed as a disease based principally on genetics. Nevertheless, genetic events occur at low ...
Epigenetic dysregulation is increasingly appreciated as a hallmark of cancer, including disease initiation, maintenance and therapy resistance. As a result, there have been advances in the development and evaluation of epigenetic therapies for cancer, revealing substantial promise but also challenges. Three...
PlncRNA-1 was found to be overexpressed in 71.43% of bladder cancer tissues. Moreover, the expression level correlated with tumor invasion, T stage, age, and number of tumors, but not with gender, recurrent status, preoperative treatment, pathological grade, and tumor size. The expression ...