In this chapter, you will learn how epigenetic modifications control the development, proliferation, and self-renewal of stem cells, and how these modifications also play important roles in cell fate decisions such as differentiation, de-differentiation, and transdifferentiation. The chapter covers ...
Compelling evidence have demonstrated that bulk tumors can arise from a unique subset of cells commonly termed “cancer stem cells” that has been proposed to be a strong driving force of tumorigenesis and a key mechanism of therapeutic resistance. Recent advances in epigenomics have illuminated key ...
Thematic series: Epigenetics in stem cells and cancer Jing Huang Cell & Bioscience20133:38 CommentaryPublished on:9 October 2013 Follow BMC By using this website, you agree to ourTerms and Conditions,Your US state privacy rights,Privacy statementandCookiespolicy.Your privacy choices/Manage cookieswe...
Such advances in stem cell biology would have a high impact on the research fields of cancer stem cell and regenerative medicine. In this review, we discuss the recent progress in understanding the roles of H3K4 methylation modifiers in regulating embryonic and adult stem cells' fates. 展开 ...
Compelling evidence have demonstrated that bulk tumors can arise from a unique subset of cells commonly termed "cancer stem cells" that has been proposed to be a strong driving force of tumorigenesis and a key mechanism of therapeutic resistance. Recent advances in epigenomics have illuminated key ...
Stem cellsEpigeneticsChromatinDNA methylationPolycombCancerEpigenetics is the study of heritable changes in gene expression that occur independently of alterations in the primary DNA sequence. Normal development requires a carefully orchestrated epigenetic program on both a global and gene-specific/tissue-...
caused by epigenetic alterations in stem cells. Additionally, the book discusses the potential implementation of stem cell epigenetics in drug discovery, regenerative medicine, and disease treatment.Stem Cell Epigeneticswill provide researchers and physicians with a state-of-the-art map to orient across...
Wu H, D'Alessio AC, Ito S, Xia K, Wang Z, Cui K, Zhao K, Sun YE, Zhang Y (2011) Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells. Nature 473, 389-393 Pastor WA, Pape UJ, Huang Y, Henderson HR, Lister R, Ko M, McLoughlin EM, Brudno Y, ...
Efforts to understand early embryonic molecular phenotypes have driven the derivation of mammalian embryonic stem cells that represent the pre- and postimplantation embryo, termed nave and primed embryonic stem cells. Here, we describe in detail mouse and human embryonic stem cell derivation as it ...
An athletic team of researchers instructed by Jing Qu, Weiqi Zhang, and Guang-Hui Liu (University of Chinese Academy of Sciences) knew of metformin’s potential to slow aging in various models, alleviate senescence in human cells, and reduce mortality […] ...