Cancer stem cells (CSCs) define a small, unique subset of cells with self-renewal ability and the capacity to generate the different cell types that constitute the whole tumor [1]. These cells are termed CSCs because of their “stem-like” properties commonly shared with normal tissue stem ce...
Compelling evidence have demonstrated that bulk tumors can arise from a unique subset of cells commonly termed “cancer stem cells” that has been proposed to be a strong driving force of tumorigenesis and a key mechanism of therapeutic resistance. Recent advances in epigenomics have illuminated key ...
doi:10.1002/9780470391594.ch10Kenneth NephewCurt BalchTim H.㎝. HuangZhang ShuPearlly YanJohn Wiley & Sons, Inc.Epigenetics in Cancer Stem Cell Development (Kenneth Nephew, Curt Balch, Tim H.M-Huang, Zhang Shu, Michael Chan, and Pearlly Yan)....
Compelling evidence have demonstrated that bulk tumors can arise from a unique subset of cells commonly termed "cancer stem cells" that has been proposed to be a strong driving force of tumorigenesis and a key mechanism of therapeutic resistance. Recent advances in epigenomics have illuminated key ...
genetic and epigenetic changes. Emerging evidence suggests that cancer cells use similar epigenetic alterations that occur during stem cell differentiation. This series summarizes the epigenetic events in cancer and stem cells and tries to stimulate the discussion on the concept of ‘cancer stem cells’...
The last few years has seen growing interest in the function of epigenetics in cancer initiation and progression. A growing volume of work now underpins our understanding of the role of these non-genetic modifications in the molecular biology of disease initiation and metastatic spread, and how ...
Recent studies have described new epigenetic mechanisms by which H3K4 methylation modifiers control self-renewal and lineage commitments of stem cells. Such advances in stem cell biology would have a high impact on the research fields of cancer stem cell and regenerative medicine. In this review, ...
Metabolic rewiring in cancer cells provides advantages not only through direct metabolic functions, but also by acting on the epigenetic landscape. Cell signalling has long been known to affect nutrient uptake and use. However, metabolism also feeds back onto signalling pathways to play an active ...
Epigenetics in cancer. Epigenetic mechanisms are essential for normal and maintenance of tissue-specific gene expression patterns in . Disruption of epigenetic processes can lead... M Esteller - 《New England Journal of Medicine》 被引量: 6099发表: 2008年 Cancer stem cells |[ndash]| old concepts...
including cancer. Stem cells have the capacity to self-renew indefinitely. Similar to stem cells, some malignant cells have the capacity to divide indefinitely and are referred to as cancer stem cells. In recent times, direct correlation between epigenetic modifications and reprogramming of stem cell...