As a critical component of the tumor microenvironment(TME),cancerassociated fibroblasts(CAFs)play important roles in cancer initiation and progression.Well-known signaling pathways,including the transforming growth factor-尾(TGF-尾),Hedgehog(Hh),Notch,Wnt,Hippo,nuclear factor kappa-B(NF-魏B),Janus ...
Of note, one of the most important characteristics of the MAPK pathway in the crosstalk between CAFs and cancer cells (Fig. 4), we propose, is the extensive cross-signaling between MAPK pathways and other cascades, such as PI3K/AKT signal, JAK/STAT cascade, and TGF-β pathway, in various...
Since Warburg discovered aerobic glycolysis as a metabolic marker of cancer cells, extensive studies have enhanced our understanding of the metabolic changes in cancer cells.1,2,3,4,5Metabolic reprogramming is a common feature of many tumors, enabling cancer cells to meet their specific growth requi...
Preis M,Korc M.Signaling pathways in pancreatic cancer. Critical Reviews in Eukaryotic Gene Expression . 2011Preis M, Korc M. Signaling pathways in pancreatic can- cer. Crit Rev Eukar Gene Exp 2011; 21:115-29; PMID:22077151; http://dx.doi.org/10.1615/ CritRevEukarGeneExpr.v21.i2.20...
Signaling Pathways in Cancer 来自 Springer 喜欢 0 阅读量: 40 作者: D Kalderon 摘要: No Abstract available for this chapter. 关键词: Keywords autophagy glomerular disease inflammation podocyte podocytopathies signaling pathways DOI: 10.1007/978-1-59745-470-4_8 被引量: 6 年份: 2008 ...
The Cancer Genome Atlas Research NetworkSanchez-Vega, F.; Mina, M.; Armenia, J.; Chatila, W.K.; Luna, A.; La, K.C.; Dimitriadoy, S.; Liu, D.L.; Kantheti, H.S.; Saghafinia, S.; et al. Oncogenic signaling pathways in the cancer genome atlas. Cell 2018, 173, 321-337. ...
Correlation of FOXO and other pathways in cancer The PI3K/AKT pathway promotes cell survival by phosphorylating and thus inhibiting the action of multiple signaling proteins like FOXO transcription factors [95]. Multiple studies supported the oncogenic role of the PI3K/AKT pathway in cancer cells ...
Wnt/β-catenin signaling is implicated in many physiological processes, including development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/β-catenin signaling is highly activated, which has led to the development of various Wnt signaling inhibitors for cancer therapies. Nonetheless...
Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide. Its complexity is influenced by various signal transduction networks that govern cellular proliferation, survival, differentiation, and apoptosis. The pathog