signaling pathways.These signals in CAFs exhibit their own special characteristics during the cancer progression and have the potential to be targeted for anticancer therapy.Therefore,a comprehensive understanding of these signaling cascades in interactions between cancer cells and CAFs is necessary to ...
Since Warburg discovered aerobic glycolysis as a metabolic marker of cancer cells, extensive studies have enhanced our understanding of the metabolic changes in cancer cells.1,2,3,4,5Metabolic reprogramming is a common feature of many tumors, enabling cancer cells to meet their specific growth requi...
In recent years, increasing evidence has suggested that abnormal activation of signaling pathways is a critical event in cancer pathogenesis. In particular, activation of these pathways can lead to inappropriate cellular survival, proliferation, pluripotency, invasion, metastasis, and angiogenesis. Thus, ...
cancer energy metabolism, and resistance to chemotherapy. For instance, oncogenic Notch signaling facilitates T-ALL cell proliferation by activating nuclear factor-kappa B (NF-κB) through Asb2 mediation.13Additionally, activated Notch signaling contributes to the acquisition of stem-like properties in e...
Of note, one of the most important characteristics of the MAPK pathway in the crosstalk between CAFs and cancer cells (Fig. 4), we propose, is the extensive cross-signaling between MAPK pathways and other cascades, such as PI3K/AKT signal, JAK/STAT cascade, and TGF-β pathway, in various...
Signaling pathways in pancreatic cancer. Crit Rev Eukaryot Gene Exp. 2011;21(2):115‐129.M. Preis and M. Korc :, "Signaling pathways in pancreatic cancer," Critical Reviews in Eukaryotic Gene Expression, vol. 21, no. 2, pp. 115-129, 2011....
Selectively targeting cancer stem cells (CSC) or tumor-initiating cells (TIC; from this point onward referred to as CSCs) with novel agents is a rapidly em... N Takebe,SP Ivy - 《Clinical Cancer Research》 被引量: 214发表: 2010年 Developmental signaling pathways in cancer stem cells of so...
becomes apparent how the highly dose-sensitive nature of developmental signaling pathways like Wnt renders them prime candidates for miRNA regulation. Merging activity-based or expression-based screens with new RNA-based therapeutics may offer opportunities for targeting Wnt signaling pathways in cancer. ...
2. cGAS/STING signaling pathway is crucial in maintaining cellular homeostasis The cGAS/STING pathway can be classified into canonical and non-canonical signaling pathways (Fig. 2) (Kumar, 2019, Kumar, 2021). Canonical cGAS/STING signaling governs IRF3-dependent type 1 IFN generation and NF-κB...
图书Signaling Pathways in Squamous Cancer 介绍、书评、论坛及推荐