In cancer cells, oncogenic signalling pathways deregulate the activity of the SREBP transcription factors and MVA pathway enzymes. Deregulated production of MVA pathway metabolites modulates multiple signalling pathways in cancer cells and contributes to transformation. Clinical trials to evaluate the utility...
The MAP kinase pathway (or, better, the MAP kinase pathways) is certainly one of the main proliferation pathways, the best known and the one whose oncogenic alterations have elicited the highest number of studies devoted to these alterations. This pathway is activated downstream numerous membrane ...
领导这一研究的是麻省理工David H. Koch 癌症研究所Michael B. Yaffe教授,Yaffe教授是Science Signalling科技期刊主编,主要从事癌症细胞信号研究,曾设计多种模型用于细胞信号通路研究,比如进行蛋白磷酸化预测的Scansite。 信号通路的串扰(Crosstalk)和复杂性,以及由于致癌基因引起的信号通路波动,都会影响到通过逐个组件来分析...
lung, and colorectal cancer. Approximately 45% of CRC harbour KRAS mutations, most commonly in the hotspot codons 12, 13 or 61 [25]. Oncogenic mutations render KRAS insensitive to GAP-mediated GTP hydrolysis and lock KRAS in an active GTP-bound conformation; ...
DNA damage signalling guards against activated oncogenes and tumour progression. Oncogene 26, 7773–7779 (2007). CAS PubMed Google Scholar Bartkova, J. et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434, 864–870 (2005). CAS PubMed ...
嵌合抗原受体T细胞(CAR-T)疗法已在血液肿瘤治疗中取得了显著的疗效,但在实体瘤治疗中却进展缓慢。相比T细胞,巨噬细胞(macrophage,M)在实体瘤微环境中不仅具有较强的肿瘤组织浸润能力,而且具有促进抗原提呈和增强T细胞杀伤活性的作用[1]。因...
Interestingly, chronic exposure of human melanocytes to high insulin and glucose levels led to enhanced proliferation and shifts in cellular signalling pathways resembling cancer cells even after a return to standard culture conditions [18]. Insulin is also essential for the survival of rat mammary ...
This review will focus on the latest evidence relating to the role of PAK family kinases in the cell signalling pathways that drive cancer cell migration and invasion. 展开 关键词: Animals Humans Mice Signal Transduction Protein Structure, Tertiary p21-Activated Kinases Neoplasm Invasiveness Neoplasms ...
•Errorsincellularinformationprocessingareresponsiblefordiseasessuchascancer,autoimmunity,anddiabetes.•Byunderstandingcellsignalling,diseasesmaybetreatedeffectivelyand,theoretically,artificialtissuesmaybecreated.•Signaltransductionoccurswhenanextracellularsignalingmoleculeactivatesaspecificreceptorlocatedonthecellsurfaceorinside...
Mammalian target of rapamycin (mTOR) regulates cell proliferation, autophagy, and apoptosis by participating in multiple signaling pathways in the body. Studies have shown that the mTOR signaling pathway is also associated with cancer, arthritis, insulin resistance, osteoporosis, and other diseases. The...