WikiPathways中的每一个通路都有自己专属的页面,呈现该通路最新的图解、描述、引用、下载选项、版本历史以及成分基因和蛋白质列表。 4.Reactome:http://www.reactome.org/ Reactome是一个免费开源的通路数据库,提供直观的生物信息学工具,用于可视化...
signaling pathways in Sertoli cells are abnormal. Clarifying the mechanisms of signaling pathways in Sertoli cells on spermatogenesis provides new insights into the physiological functions of Sertoli cells in male reproduction, and also serves as a pre-requisite to identify potential therapeutic targets in...
We have used GT1-1 cells to study the role of the cyclic AMP/protein kinase A, cyclic GMP/protein kinase G and Ca2+/protein kinase C signaling pathways in the regulation of GnRH secretion. Superfusion of GT1-1 cells with the cyclic AMP analog 8-Br-cyclic AMP (0.5 and 2.5 mM) or ...
XiHuang, ...RuiGu, inInternational Journal of Biological Macromolecules, 2023 5.4.6Wnt pathway TheWnt signaling pathwayis a complex set of signal transduction pathways that are activated when ligand proteins bind to membrane protein receptors. This pathway allows signals from outside the cell to be...
Cell Signaling Pathways in Development Cell signaling pathways are crucial in the development of organisms. These pathways are complex networks of biochemical reactions that enable cells to communicate with each other, allowing them to coordinate their activities and ultimately form tissues and organs. ...
The T-Cell Receptor (TCR) is a complex of integral membrane proteins that participates in the activation of T-Cells in response to the presentation of antigen. Stimulation of TCR is triggered by MHC (Major Histocompatibility Complex) molecules on Antigen Presenting Cells that present antigen peptide...
Zhao, A. et al. (2011) Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis. Advanced Drug Delivery Reviews 63: 610-615. Salanueva, I.J. (2007) Integrin regulation of caveolin function. J. Cell. Mol. Med. 5: 969-980. ...
function as inhibitors of RA-linked signaling systems. This review will generally introduce the risk factor and pathogenesis of RA, mainly describing the signal transduction pathways that impact RA, drugs in clinical use, potential drugs in clinical/pre-clinical studies, and technologies for targeted ...
An overlap of regulated proteins, especially those that are cytoskeleton-associated, was observed when compared with the phosphoproteome of Shigella-infected cells. We determined the biological relevance of the phosphorylation of a novel protein in EPEC pathogenesis, septin-9 (SEPT9). Both siRNA ...
Cell Communication and Signaling is an open access journal that encompasses all basic and translational aspects of cellular communications and signaling pathways in normal and pathological conditions. Genetic and epigenetic changes, cell-cell, cell-environment and cell-pathogen interactions often modulate or...