In this chapter we will explain what cell signaling is, how it works, what it serves for and especially why it is important in the context of cancer. The basics about three key signaling pathways, JAK/STAT, MEK/ERK and PI3K/Akt/mTOR, which are frequently involved in all different types ...
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梅斯学术小编将给大家分享一篇9分的SCI佳作:来自中国农业大学的科学家们在Nature出版集团旗下刊物《cell death & disease》发表了题为“Mitochondrial carrier 1 (MTCH1) governs ferroptosis by triggering the FoxO1-GPX4 axis-mediated ...
来自辛辛那提大学的癌症研究人员发现了一个新靶点,有可能促成针对一种罕见肿瘤的新疗法。研究结果在线发表在11月19日的《癌细胞》(Cancer Cell)杂志上。 生物通报道 来自辛辛那提大学的癌症研究人员发现了一个新靶点,有可能促成针对一种罕见肿瘤的新疗法。研究结果在线发表在11月19日的《癌细胞》(Cancer Cell)杂志上...
这一机制有可能发挥了至关重要的作用,使得癌细胞能够在它们快速分裂及代谢超速运转时承受住巨大的压力(延伸阅读:华人学者Cancer Cell揭示癌症代谢新机制)。 发表在12月3日《细胞》(Cell)杂志上的一篇新研究论文详细描述了这一主控开关,其似乎在肺癌及乳腺癌中发挥了关键作用,有可能成为未来抗癌药物一个有前景的靶点。
(Oncogenic) Signaling from Cancer Cells to the TME 肿瘤信号通路与TME的关系 TME中,关注肿瘤细胞内在信号通路变化与T细胞的排斥或浸润的关系是一种新治疗策略。Spranger et al.证明了黑素瘤中β-catenin激活的增强导致T细胞排斥,指出黑素瘤细胞固有的致癌途径可能通过调节DC激活来影响T细胞向TME浸润20。