c‐Jun N‐terminal kinase (JNK) is involved in cancer cell apoptosis; however, emerging evidence indicates that this Janus signaling promotes cancer cell survival. JNK acts synergistically with NF‐κB, JAK/STAT, and other signaling molecules to exert a survival function. JNK positively regulates ...
JNK signaling in cancer cell survival. Med. Res. Rev. 39, 2082–2104 (2019). Article PubMed CAS Google Scholar Lin, A. & Dibling, B. The true face of JNK activation in apoptosis. Aging Cell 1, 112–116 (2002). Article PubMed CAS Google Scholar Dhanasekaran, D. N. & Reddy,...
Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family members function in a cell context-specific and cell type-specific manner to integrate signals that affect proliferation, differentiation, survival and migration. Consistent with the importance of these events in tumori...
作为经典的信号通路,AKT/mTOR通路也被报道介导抗肿瘤药物诱导的细胞凋亡和自噬。 2019年5月3日,Journal Of Experimental & Clinical Cancer Research(IF:11.3)杂志上刊登了题为“Celastrol mediates autophagy andapoptosis via the ROS/JNK and Akt/mTORsignaling pathways in glioma cells”的研究论文,研究了雷公藤红...
Fig 2 JNK signaling pathwayCytokines:细胞因子;Growth factors:生长因子;Viral bacteria:病毒细菌;Anticancer drugs:抗癌药物;Radiation:辐射;Heat shock:热休克;Small GTPases:小G蛋白;Other signal collecting proteins:其它信号募集蛋白;Cell shape changes:细胞形状改变;Cell differentiation:细胞分化;Cell survival:细胞...
cAMP signaling selectively influences Ras effectors pathways Thyrotropin (TSH) stimulates survival and growth of thyroid cells via a seven transmembrane G protein-coupled receptor. TSH elevates the intracellular cycl... I Ciullo,G Diez-Roux,MD Domenico,... - 《Oncogene》 被引量: 247发表: 2001年...
kinaseisasubstrateforc-JunN—termina1kinaseinthehuman centra1nervoussystem.Proc.Nat1.Acad.Sci.U.S.A.,95. 2586—2591. [243FerrerI,PlanasAM.Signalingofcelldeathandcellsurvival followingfocalcerebralischemia:lifeanddeathstruggleinthe penumbra.JNeu—ropatholExpNeurol,2003,62:329—339. ...
Gespach, C., and Atfi, A., 2000, Differential roles of JNK and Smad2 signaling pathways in the inhibition of c-Myc-induced cell death by TGF-β... Mazars,Anne,Tournigand,... - 《Oncogene》 被引量: 36发表: 2000年 Activated type I TGFβ receptor kinase enhances the survival of mamm...
crease of intracellular drug accumulation ，enhancement of DNA damage and repair function ，increase of cell detoxification function ，disturbance of apoptosis signal-transduction and abnormality of apoptosis inhibitor.Among them ，apoptosis and survival related cell signal pathways are the hotspots now.p38...
Alternative splicing at the COOH terminus of the three JNK genes yields proteins that are either 46 or 54 kDa in size. Temporal regulation of JNK may also be a critical determinant of cellular responses: JNK1 transient activation, for example, promotes cell survival, whereas prolonged activation ...