Cholesterol and its derivatives in Sonic Hedgehog signaling and cancer. Curr. Opin. Pharmacol. 12, 736–741 (2012). Article CAS PubMed PubMed Central Google Scholar Eaton, S. Multiple roles for lipids in the Hedgehog signalling pathway. Nat. Rev. Mol. Cell. Biol. 9, 437–445 (2008)....
空间分离的巨噬细胞群体可预测结肠癌的不同结果 Cancer Discovery——[28.2] ① 通过分析scRNA-seq及空间转录组测序数据,结合免疫组化染色和CODEX图像,在正常和恶性人类乳腺和结肠组织中鉴定出5种不同的人类巨噬细胞类群;② 不同的巨噬细胞群体分布在不同的微环境生态位中,并展现出保守的细胞组成,这种分布模式在健...
Cell-in-cell structures are reported in numerous cancers, and their presence is an indicator for poor prognosis. Mechanistic studies have identified how cancer cells manage to ingest whole neighbouring cells to form such structures, and the consequences of cell-in-cell formation on cancer progression...
空间分离的巨噬细胞群体可预测结肠癌的不同结果 Cancer Discovery——[28.2] ① 通过分析scRNA-seq及空间转录组测序数据,结合免疫组化染色和CODEX图像,在正常和恶性人类乳腺和结肠组织中鉴定出5种不同的人类巨噬细胞类群;② 不同的巨噬细胞群体分布在不同的微环境生态位中,并展现出保守的细胞组成,这种分布模式在健...
2022年1月15日,扬州大学临床医学院苏北人民医院普外科研究所Huan Zhang团队在Cell Communication and Signaling上发表了题为“Exosomes: the key of sophisticated cell–cell communication and targeted metastasis in pancreatic cancer”的综述性论文。在本文中,团队就PaCa来源的外泌体转运信号功能、介导细胞间通讯以及调...
A Histochemical Approach to the Diagnosis of Visceral Pleural Infiltration by Non-small Cell Lung Cancer Introduction: Although invasion of the visceral pleura (VPI) by non-small cell lung cancer (NSCLC) is a TNM-relevant diagnostic criterion and is known to a... Arne,Warth,Thomas,... - 《...
cancer diagnosis [71] and prognosis prediction [72], increase the understanding of disease progression and cancer metastasis [73,74], and guide therapy [75] (Table2). Recently, to deepen the understanding of tumor heterogeneity, single-cell sequencing technologies are often combined with other ...
Table 1 Select recent clinical trials of novel targeted therapies in small-cell lung cancer Full size table Signaling pathways targeting the cell cycle and DNA repair Poly (ADP-ribose) polymerase (PARP) PARP enzymes, activated by binding single-strand DNA breaks (SSB), belong to a family of ...
toll-like receptor signaling pathway, and JAK-STAT and MAPK signaling. Cluster 5 was associated with B cell receptor signaling and major histocompatibility complex (MHC) class II antigen presentation. Cluster 4 was enriched in cell cycle set and intrinsic signaling, such as the JAK-STAT and MAPK...
Cancer cells within a tumour have heterogeneous phenotypes and exhibit dynamic plasticity. How to evaluate such heterogeneity and its impact on outcome and drug response is still unclear. Here, we transcriptionally profile 35,276 individual cells from 32