CancerThe Ras/Raf/MEK/ERK and PI3K/Akt/mTOR cascades are often activated by genetic alterations, either by mutations in upstream signaling molecules or by mutations in intrinsic pathway components. Upstream mutations in one signaling pathway or even in downstream components of the same pathway can ...
Lymphocytes and other hematopoietic cells are excellent models for the study of metabolic regulation because quiescent cells can be stimulated to proliferate in vitro and the signaling mechanisms behind cell proliferation are well characterized. Tumor cells are also useful because a wide variety of cell...
crucial cytosolic PRR system.Altered cGAS/STING signaling supports a precancerous environment and metastasis.The cGAS/STING pathway also serves as a potential prognostic biomarker in different cancers.Current cancer therapies indirectly affect cGAS/STING signaling in tumor cells for their anticancer ...
自2000年以来共发表研究论文30余篇,其中SCI论文21篇,主要研究成果发表于Molecular and Cellular Biology, Cancer Research, International Journal of Oncology,CELL, BBRC, Cell Research, Hepatology, International Journal of Cancer等国际著名杂志。申请国家发明专利3项,获得授权1项。获上海医学科技奖2等奖1项(第1...
This section aims to provide a platform for the communication and dissemination of advances in cancer biology and their translational applications. Studies considered for publication include those dissecting the mechanisms of transformation, progression and metastatization, the biology of cancer stem cells ...
Activating cGAS/STING generates type 1 IFN, which may prevent cellular transformation and cancer development, growth, and metastasis. The current article delineates the impact of the cancer cell-specific cGAS/STING signaling pathway alteration in tumors and its impact on tumor growth and metastasis. ...
【英文原版】Molecular Biology of the Cell细胞分子生物学第6版 pdf epub mobi txt 电子书 下载 具体描述 编辑推荐As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and ...
Cancer is a group of diseases in which cells divide continuously and excessively. Cell division is tightly regulated by multiple evolutionarily conserved cell cycle control mechanisms, to ensure the production of two genetically identical cells. Cell cyc
(2025). "Targeting Smurf1 to block PDK1–Akt signaling in KRAS-mutated colorectal cancer."Nature Chemical Biology21(1): 59-70.(20240722,国家蛋白质科学中心,张令强,崔春萍;清华大学,饶燏;南方医科大学,张学利)揭示了E3连接酶SMAD泛素化调节因子1 (Smurf1)介导的磷酸肌苷依赖性蛋白激酶1 (PDK1)拟素化...