Lymphocytes and other hematopoietic cells are excellent models for the study of metabolic regulation because quiescent cells can be stimulated to proliferate in vitro and the signaling mechanisms behind cell proliferation are well characterized. Tumor cells are also useful because a wide variety of cell...
CancerThe Ras/Raf/MEK/ERK and PI3K/Akt/mTOR cascades are often activated by genetic alterations, either by mutations in upstream signaling molecules or by mutations in intrinsic pathway components. Upstream mutations in one signaling pathway or even in downstream components of the same pathway can ...
[19] Yang X, Wang H, et al. Rewiring ERBB3 and ERK signaling confers resistance to FGFR1 inhibition in gastrointestinal cancer harbored an ERBB3-E928G mutation. Protein Cell. 2020 Dec.(IF:14.872)浙江大学医学院/转化医学研究院闵军霞团队 [20] Zou Y, Wang A, et al. Analysis of redox land...
Factor-1alpha Potentiates Jagged 1-Mediated Angiogenesis by Mesenchymal Stem Cell-Derived Exosomes. Stem Cells35, 1747, doi:10.1002/stem.2618 (2017).8. Meurette, O. et al. Notch Signaling in the Tumor Microenvironment. Cancer Cell34, 536, doi:10.1016/j.ccell.2018.07.009 (2018).
crucial cytosolic PRR system.Altered cGAS/STING signaling supports a precancerous environment and metastasis.The cGAS/STING pathway also serves as a potential prognostic biomarker in different cancers.Current cancer therapies indirectly affect cGAS/STING signaling in tumor cells for their anticancer ...
Figure. miRNA maturation and function. Source:Macfarlane LA, Murphy PR. MicroRNA: Biogenesis, Function and Role in Cancer. Curr Genomics. 2010 Nov;11(7):537-61.doi: 10.2174/138920210793175895. The following is an interview in the journal Journal of Cellular Biology with Dr, Victor Ambros on ...
Cancer Signaling: From Molecular Biology to Targeted Therapy 作者:Christoph Wagener/Carol Stocking/Oliver Müller 出版社:Wiley-Blackwell 出版年:2016-12-12 页数:360 装帧:Paperback ISBN:9783527336586 豆瓣评分 评价人数不足 评价: 写笔记 写书评 加入购书单 分享到 推荐...
自2000年以来共发表研究论文30余篇,其中SCI论文21篇,主要研究成果发表于Molecular and Cellular Biology, Cancer Research, International Journal of Oncology,CELL, BBRC, Cell Research, Hepatology, International Journal of Cancer等国际著名杂志。申请国家发明专利3项,获得授权1项。获上海医学科技奖2等奖1项(第1...
Cancer is a group of diseases in which cells divide continuously and excessively. Cell division is tightly regulated by multiple evolutionarily conserved cell cycle control mechanisms, to ensure the production of two genetically identical cells. Cell cyc
7. Gonzalez-King, H. et al. Hypoxia Inducible Factor-1alpha Potentiates Jagged 1-Mediated Angiogenesis by Mesenchymal Stem Cell-Derived Exosomes. Stem Cells 35, 1747, doi:10.1002/stem.2618 (2017). 8. Meurette, O. et al. Notch Signaling in the Tumor Microenvironment. Cancer Cell 34, 536,...