The high glucose uptake and activation of oncogenic signaling pathways in cancer cells has long made these features, together with the mutational spectrum, prime diagnostic targets of circulating tumor cells (CTCs). Further, an ability to characterize these properties at a single cell resolution is ...
In the next section, we will discuss specific targets of Trx1 and how Trx1 affects their function. Show abstract Thioredoxin Signaling Pathways in Cancer 2023, Antioxidants and Redox Signaling Dysregulation of CRMP2 Post-Translational Modifications Drive Its Pathological Functions 2019, Molecular ...
Tumor cells depend on a complex set of respiratory pathways to generate the necessary energy as well as redox-sensitive pro-survival signaling pathways and factors to cope with and defend against the detrimental effects of oxidative stress. It has been hypothesized that redox-sensitive signaling ...
Redox regulation of metabolic and signaling pathways by thioredoxin and glutaredoxin in NOS-3 overexpressing hepatoblastoma cells - ScienceDirect Padilla, Redox regula- tion of metabolic and signaling pathways by thioredoxin and glutaredoxin in NOS- 3 overexpressing hepatoblastoma cells, Redox Biol. 6......
Molecular targets, redox signaling, anticancer drug resistance, thioredoxin; 机译:分子靶标;氧化还原信号传导;抗癌药耐药性;硫氧还蛋白; 入库时间 2022-08-17 23:21:22 相似文献 外文文献 中文文献 专利 1. Thioredoxin and thioredoxin reductase as redox-sensitive molecular targets for cancer therapy. ...
From:Cancer Drug Design and Discovery (Second Edition),2014 About this page Add to MendeleySet alert Chapters and Articles You might find these chapters and articles relevant to this topic. Thiol Redox Transitions in Cell Signaling, Part B: Cellular Localization and Signaling ...
Here, we review the novel functional concept of the redox-related protein complex, named "Redoxisome," consisting of Trx/Txnip, as a critical regulator for intra- and extra-cellular redox signaling, involved in the pathogenesis of various diseases such as cancer, autoimmune disease, and diabetes...
All three mammalian Prx proteins (Prx I, II, and III) were shown to exhibit peroxidase activity toward H202 in the presence of the thioredoxin system (thio... Chae,H Zoon - 《Methods Enzymol》 被引量: 791发表: 1999年 Glutathionylation of chloroplast thioredoxin f is a redox signaling mec...
Perspectives of the Nrf-2 signaling pathway in cancer progression and therapy PriyankaBasak, ...Parames C.Sil, inToxicology Reports, 2017 5.3.2.3Renal and urinary bladder carcinoma Inurothelial bladder carcinomathere is mutations inthioredoxininteracting protein (TXNIP) gene mutually exclus...
Addition- ally, the mitochondria are a major source of reactive oxygen species (ROS) and substantial evidence suggests that ROS could play important roles in altering cellular signaling pathways [55-57], which could have a more significant impact on aging than the accumulation of oxidative damage....