cancer therapyselenocysteinereactive oxygen speciesThioredoxin (Trx) and thioredoxin reductase (TrxR) are essential components of the Trx system which plays pivotal roles in regulating multiple cellular redox signaling pathways. In recent years TrxR/Trx have been increasingly recognized as an important ...
GarthPowis,D LynnKirkpatrick, inCurrent Opinion in Pharmacology, 2007 Thioredoxin(Trx) family members play critical roles in the regulation of cellular redox homeostasis. Cancer cells exist in a stressed environment and rely on the Trxs for protection against stress-disregulated redox signaling. The ...
The second example is the immunological function of ANT1 in regulating the IL-6 expression of macrophages; the mechanism involved is carried out at transcriptional level by decreasing the phosphorylation of JNK, one of the main signaling pathways involved in accelerating the transcription of ...
We show here that 4~5 µM AF induces paraptosis, a non-apoptotic cell death mode characterized by dilation of the endoplasmic reticulum (ER) and mitochondria, in breast cancer cells. Although the covalent inhibition of thioredoxin reductase (TrxR), an enzyme that critically controls ...
Inhibition of Trx1 and Grx1 could, therefore, have pro-apoptotic effects in cancer cells23,29. Here we investigated the potential interactions between APR-246/MQ and Trx1 and Grx1, and found that reaction of MQ with both Trx1 and Grx1 was associated with loss of free thiols in both ...
In contrast, Sep15 mRNA was decreased by up to 50% when cells were exposed to 5-methoxyflavone, 5-hydroxy-7-methoxyflavone, 7-hydroxyflavone or resveratrol, which are known to affect aryl hydrocarbon receptor signaling. Surprisingly, sulforaphane decreased Sep15 mRNA expression in shTR1 cells. ...
We studied the RNA expression of the genes in response to glucose from 5 mM (condition of normoglycemia) to 20 mM (condition of hyperglycemia/diabetes) by microarray analysis in breast cancer derived cell line MDA-MB-231. We identified the thioredoxin-interacting protein (TXNIP), whose RNA le...
Western blot analysis of different and paired breast tissues revealed consistent and preferential expression of Prx I and Trx1 protein in breast cancer tissue. Conclusion Prx I and Trx1 are overexpressed in human breast carcinoma and the expression levels are associated with tumor grade. The ...
Thioredoxin Signaling Pathways in Cancer 2023, Antioxidants and Redox Signaling Thymol induces mitochondrial pathway-mediated apoptosis via ROS generation, macromolecular damage and SOD diminution in A549 cells 2021, Pharmacological Reports Exploring the underlying mechanism of action of a traditional Chinese ...
Moreover, thioredoxins have also been implicated in several human disorders such as diabetes, heart disease, and cancer. In plants, the first thioredoxin system was identified in chloroplasts in the late 1970s (Schürmann et al., 1976; Wolosiuk and Buchanan, 1977). This system was different ...